喷雾干燥技术在蛋白、多肽类药物微球制备中的应用  

Application of Spray Drying Technique to Preparation of Protein and Peptide-loaded Microspheres: a Review

作　　者：白洁[1] 何应[1] 

机构地区：[1]天津大学药物科学与技术学院,天津300072

出　　处：《药学进展》2007年第7期298-302,共5页Progress in Pharmaceutical Sciences

摘　　要：按照不同的常用载体材料(聚乳酸类和壳聚糖类),分类综述应用喷雾干燥技术制备蛋白、多肽类药物微球的研究进展,主要介绍和比较了溶液/喷雾干燥、乳剂/喷雾干燥、喷雾冷冻干燥、喷雾液中冷冻及低温喷雾提取等制备工艺的特点。According to different kinds of common carrier materials： PLA, PLGA and chitosan, the advances in application of spray drying technique to preparation of protein- and peptide-loaded microspheres were reviewed classifiedly. And the characteristics of major spray drying techniques, such as solution/spray-drying, emulsion/ spray-drying, spray freeze drying, spray freezing into liquid and cryogenic spray extraction, were introduced and compared.

关 键 词：喷雾干燥 微球 聚乳酸 壳聚糖 蛋白 多肽 

分 类 号：R94[医药卫生—药剂学]