国产甲磺酸托烷司琼防治顺铂引起呕吐的成本-效果分析  

Cost-effectiveness Analysis of Home-made Tropisetron Mesylate in the Prevention of Cisplatin-induced Vomiting

作　　者：丁罡[1] 程华丰[2] 张明[1] 杨忠英[1] 

机构地区：[1]上海交通大学医学院附属仁济医院崇明分院,202150 [2]上海交通大学医学院附属仁济医院,200127

出　　处：《实用癌症杂志》2007年第4期398-400,共3页The Practical Journal of Cancer

摘　　要：目的探讨国产托烷司琼防治顺铂所致呕吐的的经济效果。方法40例顺铂化疗患者,采用自身对照,依次给予甲氧氯普胺+地塞米松和托烷司琼进行预防呕吐治疗,运用药物经济学的成本-效果分析方法进行评价。结果2种方案预防呕吐的成本分别为77.97元和132.12元;有效率分别为52.5%和95.0%;每获得1个单位效果,2种方案所需花费的成本分别为1.49和1.39元。在方案Ⅰ的效果基础上,每再获得1个单位效果,方案Ⅱ所花费的成本为1.27元。结论方案Ⅱ为成本-效果比最低的方案,且有效率高,而增加相同的疗效需成本较低,故国产甲磺酸托烷司琼方案为较为合理的方案。Objective To evaluate the ecnomic effects of home-made tropisetron mesylate in the prevention of cisplatininduced nausea and vomiting. Methods 40 patients receiving cisplatin chemotherapy were given metoclopramide ＋ dexamethasone and tropisetron mesylate sequently to prevent vomiting by self-contrast. Data was evaluated using the pharmacoeconomic costeffectiveness analysis. Results The costs of two groups were 77.97 and 132.12 yuans respectively. The effective rates of two groups were 52.5% and 95.0% respectively. Two schemes costed 1.49 and 1.39 yuans respectively for increasing 1% effective rate. Scheme Ⅱ costed 1.27 yuans for increasing 1% effective rate basing on scheme Ⅰ. Conclusion Between the two schemes, scheme Ⅱ had a lower cost-effective ratio and higher effective rate In increasing the same efficacy. The tropisetron mesylate based scheme Ⅱ is the rational one.

关 键 词：成本-效果分析 顺铂所致呕吐 甲氧氯普胺 地塞米松 托烷司琼 

分 类 号：R730.53[医药卫生—肿瘤]