骨膦与化疗和放疗联合治疗肺癌骨转移的临床研究  

Investigation on Combination Therapy Bonefos and Chemotherapy and/or Radiotherapy for Bone Metastasis from Lung Cancer

作　　者：张艳丽[1,2,3] 张晓春[1,2,3] 张雪艳[1,2,3] 李秀菊 

机构地区：[1]山东省肿瘤防治研究院 [2]山东省立医院 [3]山东省警官总医院

出　　处：《齐鲁肿瘤杂志》1997年第2期133-135,共3页

摘　　要：本文依据５９例肺癌骨转移患者的临床资料，总结分析了肺癌骨转移的特点，着重探讨了骨膦与化疗和放疗联合治疗肺癌骨转移的疗效。结果示：骨膦治疗组３９例止痛总有效率为８７．２％，非骨膦治疗组２０例止痛总有效率为６０％，两者有显著差异（Ｐ〈０．０５）；骨膦治疗组的平均生存期（８．５个月）较非骨膦治疗组（５个月）明显延长（Ｐ〈０．０５）；骨膦治疗组较非骨膦治疗组无明显的毒性反应。另外骨膦用药的时间和疗程对疗效都有一定影响。Clinical data of bone metastasis from lung cancer were analyzed with emphasis on the characteristics of bone metastasis and the effect of combination of chemotherapy and/or radiotherapy with or without bonefos.The results were as follows:the response rate of patients who were treated by chemotherapy and/or radiotherapy with bonefos was87.2%;and that of the group without bonefos was 60%,The difference between these two response rates was significant(P<0.05).The average survival time of the group with bonefos was 8.5 months which was significantly longer than that of group without bonefos who had a average survival of 5 months(P<0.05).The toxicity were less severe in the group with bonefos than without bonefos.The modality of combination therapy and time with bonefos had affected on effect.

关 键 词：骨膦 骨转移癌 肺肿瘤 化学疗法 放射疗法 

分 类 号：R734.205[医药卫生—肿瘤]