光动力治疗恶性肿瘤临床研究  

An Clinical Studys of Photodynamic Therapy Different on Malignant Tumors

作　　者：王洪武[1] 邹珩[1] 周云芝[1] 马洪明[1] 

机构地区：[1]北京煤炭总医院肿瘤微创治疗中心,100028

出　　处：《医学研究杂志》2007年第7期35-38,共4页Journal of Medical Research

摘　　要：目的观察光动力治疗在不同肿瘤治疗中的疗效。方法45例肿瘤患者(原发性中央型肺癌20例,复发性脑胶质瘤8例。食管癌6例,胃癌、结肠癌各2例,直肠癌、舌癌、皮肤癌、喉癌术后复发、股恶性组织细胞瘤术后复发各1例)通过静脉注射光敏剂为photosan(2mg/kg),分别于注药后48h、72h照光2次。仪器为南京高功率氦氖激光治疗仪,输出中心波长630nm,总输出功率800～1000mW,能量密度为200～300J/cm(或300J/cm2),光照范围为全部敷盖病灶及近癌旁约1cm内正常组织,每光斑照射时间10～20min。结果PDT治疗后第2天即可见肿瘤坏死,表面被敷厚白苔,肿瘤及其周边组织高度充血水肿,1周后,管腔即较前明显扩大。病理光镜下见癌细胞普遍变性坏死,有空泡形成。1月后所有病例有效率为100%。结论PDT是一种微创、有效地治疗肿瘤的方法,对消化道肿瘤效果尤为明显。Objective The effects of photodynamic therapy（PDT） were observed in different malignant tumors. Methods Photosan （2mg/kg） was intravenously given in 45 cases of 20 central lung cancer, 8 recurretlt brain gliomas, 6 esophagus cancer, 2 stomach caneer, 2 colum cancer, 5 the others. Alter 48 and 72 hours later, PDT （ He - Ne Gas Laser,630um ） was performed respectively with 800 - 1000roW,energy density 200 - 300J/cm（ or 300J/cm^2 ）. More than 1 cm of normal tissue around the ttlmor was treated by laser in 10 - 20 minutes. Results Tumor necrosis could be tbund in next day of PDT, which showed that heavy white blanket covered the tumor accompanied by severe edema around the tumor. The volume of lumen cancer should be enlarged after 1 week of PDT. Necrosis and cavities could be discovered under light microscopy. The efficiency was 100% in all patients after 1 month of PDT. Conclusions PDT is a minimal. targeted and perspective therapy to tumors.

关 键 词：光动力治疗 肺癌 消化道肿瘤 脑瘤 舌癌 

分 类 号：R730.5[医药卫生—肿瘤]