N-取代苄基氢化氟哌啶醇氯化物对大鼠血流动力学的影响  

Effects of N-substituted benzyl of hydrohaloperidol chlorides on hemodynamics in rats

作　　者：何小英[1] 王锦芝[1] 郑锦鸿[1] 

机构地区：[1]汕头大学医学院化学教研室,广东汕头515041

出　　处：《广东药学院学报》2007年第3期289-292,共4页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省科技厅项目(2004B30101015);广东省自然科学基金(034614)

摘　　要：目的研究N-取代苄基氢化氟哌啶醇氯化物（FB8～FB11、FB13）对麻醉大鼠血流动力学的影响，并分析构效关系。方法麻醉正常血压SD大鼠，经右颈总动脉插管至左心室，右股动脉插管后，分别静脉注射不同目的化合物，BL420型生物机能实验系统记录观察血流动力学效应。结果与给药前相比，FB9和FB11组平均动脉压明显下降（P〈0．01）；FB13组降低（P〈0.05）的同时，心率、左心室收缩压和左心室压变化速率最大值显著降低。结论FB9和FB11具有较强的降压作用，对大鼠心功能无影响；FB13可使大鼠血压降低，并可能具有心脏抑制效应。Objective To study the effects of n-substituted benzyl of hydrohaloperidol chlorides on hemodynamics in rats and analyze structure - activity relationship. Methods Catheters were inserted into the right femoral artery and the left ventricle through right common carotid artery. After iv administration of different compounds in anaesthetized rats, hemodynamic indexes were analyzed with BL--420 biology enginery experiment system. Results Compared with corresponding pre-treatment periods, the MAP at the 1 -5 rain significantly decreased in FB9 and FBH group（P 〈 0.01 ）. FBI3 group has the effect of decreasing MAP（P 〈 0.05 ）, HR, LVSP and ± dp/dtmax on anesthetized rats. Conclusion Pharmacological studies in vivo suggested that FB9 and FB11 significantly decreased blood pressure and hardly inhibited the myocardial systolic and diastolic functions, FB13 has a hypotensive effect and chrontropic effect on the heart of rats.

关 键 词：氟哌啶醇 氢化物 血流动力学 构效关系 

分 类 号：R96[医药卫生—药理学]