光学药物压抑疗法治疗儿童中度弱视124例临床研究  

OPTICAL AND PHARMACOLOGICAL PENALIZATION FOR TREATMENT OF MODERATE AMBLYOPIA IN CHILDHOOD

作　　者：薛兆武 李军 段雪梅 戴冬梅 高金梅 姜伟萍 

机构地区：[1]枣庄矿业集团中心医院眼科,山东省枣庄市277011

出　　处：《中国煤炭工业医学杂志》2007年第8期878-880,共3页Chinese Journal of Coal Industry Medicine

摘　　要：目的研究光学药物压抑疗法治疗儿童中度弱视临床疗效。方法选取248例符合研究条件的中度弱视儿童,随机分成遮盖治疗组和光学药物压抑治疗组,每组124例。遮盖治疗组弱视眼配镜,健眼每天遮盖8h以上;光学药物压抑治疗组弱视眼配适矫镜,健眼用1%阿托品眼药水或眼药膏点眼,每周一次,戴欠矫+5.0DS镜片。结果对所有病例均进行1年以上随访,遮盖治疗组和光学药物压抑治疗组疗效差异无统计学意义(P>0.05)。在治疗的前2个月遮盖组疗效明显;年龄与弱视类型不是影响疗效的因素。5岁以上患者压抑治疗好于遮盖治疗,但差异无统计学意义。结论光学药物压抑疗法与遮盖疗法治疗儿童中度弱视具有同等疗效,而且还具有依从性好,不影响外观,不易出现遮盖性弱视等优点,应该广泛开展应用。Objective To combine optical and atropine penalization treatment （COAT）, and assessed it in children with moderate amblyopia. Methods 248 children with moderate amblyopia were selected and divided into 2 groups at random. Children in group Ⅰ （124 cases） wore full corrected glasses with the amblyopic eye and occlusion with the sound one. Children in group Ⅱ （124cases） were prescribed weekly 1% atropine drop or ointment and ＋ 5DS glasses to the sound eye while the amblyopic one wore full corrected glasses, Results There was no significant difference in efficacy between the two groups at a follow - up of more than 1 year. Patients in the occluding group had a better improvement in the first two months. Age and types of amblyopia were not related to the effect. Effect of children elder than 5 year- old showed a greater improvement in the penalization group than those in the occluding one（P〉0.05）. Conclusion Optical and pharmacological penalization show a similar effect with occlusion therapy in the treatment of moderate children amblyopia with a low risk of occlusion amblyopia. Penalization should be considered more often for the primary treatment of amblyopia.

关 键 词：光学 压抑疗法 弱视 

分 类 号：R777.440.5[医药卫生—眼科]