小儿退热解毒颗粒对发热大鼠下丘脑中PGE_2及cAMP含量的影响  

The Effect of Xiaoertuirejiedu Granule as Antipyretic

作　　者：焦平[1] 钟振环[2] 王海燕[1] 杜晨光[3] 焦建玮[3] 薛丽莉[3] 谢会卿[3] 

机构地区：[1]河北省中医院,石家庄050011 [2]河北省石家庄市中医院,石家庄050012 [3]河北医科大学,硕士生石家庄050017

出　　处：《中国中医急症》2007年第7期842-843,共2页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的探讨小儿退热解毒颗粒解热作用的机理。方法采用酵母混悬液复制大鼠发热模型,观察小儿退热解毒颗粒对发热大鼠下丘脑中PGE_2和cAMP含量的影响。结果小儿退热解毒颗粒可降低发热大鼠下丘脑中PGE_2和cAMP含量。结论小儿退热解毒颗粒可通过抑制下丘脑中PGE_2和cAMP含量升高而发挥其解热作用。Objective： To investigate the mechanism of Xiaoertuirejiedu Granule（XG） on the effect of antipyretic. Methods： Chose febrile model of rats induced by yeast suspension. Observed the effect of XG on the contents of febrile medium such as PGE2 and cAMP in hypothalamus tissue of febrile rats induced by yeast. Results： XG could increase contents of febrile medlum such as PGE2 and cAMP obviously. Conclusion： It shows that XG had antipyretic effect. The mechanism can be relevant to restrainting the synthesis or releasing of inflammatory mediator PGE2.

关 键 词：小儿退热解毒颗粒 解热 体温调节中枢 PGE2 CAMP 

分 类 号：R285.5[医药卫生—中药学]