抑胶素对大鼠脑胶质瘤P16蛋白表达影响的实验研究  

Empirical study about Antigliomation's effect on the expression of p16 protein in rats' glioma cells

作　　者：林卫红[1] 崔俐[1] 张柏民[2] 王绍[3] 

机构地区：[1]吉林大学第一医院神经内科,吉林长春130021 [2]吉林大学中日联谊医院心外科 [3]吉林大学基础医学院生理学教研室

出　　处：《中国实验诊断学》2007年第7期881-883,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技厅科研资助;编号:20050407-6

摘　　要：目的探讨不同浓度的抑胶素对大鼠脑胶质瘤p16蛋白表达的影响。方法体外培养C6胶质瘤细胞,制作大鼠脑胶质瘤模型,通过免疫组织化学染色法检测不同浓度的抑胶素对大鼠脑胶质瘤P16蛋白表达的影响。结果随着抑胶素浓度的增加,大鼠脑胶质瘤p16蛋白的表达也逐渐增强。结论抑胶素能够抑制大鼠脑胶质瘤的增殖,并且具有改变肿瘤细胞增殖周期的作用。Objective explore the Antigliomation＇ s effect in different concentration on the expression of p16 protein in rats＇ ghorna cells.Methods culture C6 glioma ceils in vitro and make the mode of rats＇ glioma, detect the effect of Antigliomation in different concentration on the expression of p16 protein in rats＇ glioma cells by immunohistochemical staining method. Results with the increase in Antigllomation＇ s concentration, expression of p16 protein in rats＇ glioma cells also reinforces gradually. Conclusion Antigliomafion can inhibit the growth of rats＇ gfioma cells, and also can alter the multiplication cycle of glioma cells.

关 键 词：抑胶素 脑胶质瘤 P16蛋白 

分 类 号：R739.41[医药卫生—肿瘤]