乳腺癌患者外周血CK5/6/18阳性细胞的检测及其临床意义  

Clinical significance of the expression rates of cytokeratin5/6/18 positive cells in peripheral blood cells from patients with breast carcinoma

作　　者：金广超[1] 臧益秀[2] 李钧[3] 陈连胜[2] 田斌[2] 王晓[2] 

机构地区：[1]山东大学医学院,山东济南250012 [2]济南市中心医院普外科,山东济南250013 [3]济南市中心医院肿瘤科,山东济南250013

出　　处：《中国现代普通外科进展》2007年第3期254-256,共3页Chinese Journal of Current Advances in General Surgery

基　　金：济南市科技发展计划资助项目(200512026)

摘　　要：目的:探讨乳腺癌患者外周血细胞角蛋白5/6/18(cytokeratin5/6/18,CK5/6/18)阳性细胞表达水平及其临床意义。方法:采用流式细胞术检测56例乳腺癌患者外周血CK5/6/18阳性细胞的表达情况。结果:56例乳腺癌患者中有26例外周血CK5/6/18细胞表达阳性,阳性率为46.4%,与健康对照人群和乳腺良性疾病患者比较,P<0.05;Ⅲ、Ⅳ期乳腺癌患者外周血中CK5/6/18阳性细胞的表达高于Ⅰ、Ⅱ期乳腺癌患者,P<0.05;ER、PR阳性的患者与阴性患者表达无显著意义(P>0.05)。结论:乳腺癌患者外周血中CK5/6/18阳性细胞的表达与乳腺癌的分期有关,可作为临床监测和判断预后的参考指标。Objectives： To investigate the clinical significance of the expression level of cy- tokeratin5/6/18 positive cells in peripheral blood cells from patients with breast carcinoma, Methods： The expression rates of ck5/6/18 positive cells in peripheral blood cells from 56 patients with breast carcinoma were measured and analyzed by flow cytometry. Results： The expression rates of ck5/6/18 positive cells in peripheral blood cells from 56 patients with breast carcinoma was 46.4% and there was significant differences compared with healthy volunteers and the patients with breast benign diseases. The positive rates increased significantly with the pathological staging and show no significant relationship with the ER and PR. Conclusion： The expression of ck5/6/18 positive cells in peripheral blood cells correlates significantly with the pathological staging of breast carcinoma and it could be an effective signal to clinical monitor and prognosis.

关 键 词：乳腺肿瘤 细胞角蛋白 

分 类 号：R737.9[医药卫生—肿瘤]