饮水锶对大鼠骨骼生长发育影响的实验研究  

The Effects of Strontium in Drinking Water on Growth and Development of Rat Bone

作　　者：徐凤丹[1,2] 张秀岭[1,2] 刘建荣[1,2] 范美云[1,2] 宋瑞霞[1,2] 白锦[1,2] 满青青 

机构地区：[1]中国预防医学科学院环境卫生监测所 [2]中国预防医学科学院营养与食品卫生研究所

出　　处：《卫生研究》1997年第3期172-178,共7页Journal of Hygiene Research

基　　金：卫生部科学基金

摘　　要：研究了高锶饮水对大鼠骨骼生长发育的影响。结果表明，饮水中锶浓度为５～５００ｍｇ／Ｌ达１２周可引起Ｗｉｓｔａｒ大鼠血清、尿、股骨、颌骨和牙齿中锶含量增高，呈明显的剂量－反应关系。同时，锶还可使骨骼钙含量降低，牙齿钙含量和骨骼的骨密度增高，以及除第１２周雌性大鼠外血清钙水平下降。尚未发现锶对动物体重、体长、血清ＡＫＰ活性、尿钙水平以及股骨弯曲断裂载荷的影响。然而，锶对动物骨骼生长发育影响性别之间存在差异，如在第１２周染锶组雄性大鼠血清钙含量降低，而雌性大鼠升高；在第４周和第８周时，仅雄性大鼠尿Ｈｏｐ／Ｃｒ比值增高，而雌性大鼠维持于正常水平；Ｓｒ２＋还使雄性大鼠颌骨骨密度增加，而雌性大鼠股骨骨密度增加。上述改变提示可能是动物性别之间在内分泌调节和代谢过程上不同的结果。Effects of strontium at a high level in drinking water on growth and development of rat bone were studied. The results showed that Sr 2+ concentration from 5 to 500mg/L in drinking water could increase the contents of strontium in blood serum, urine, femur, mixilla and tooth in Wistar rats exposed to Sr 2+ for 12 weeks with an obvious dose response relationship. In addition, strontium at over 50mg/L could decrease the contents of calcium in bone, increase the contents of calcium in tooth and bone density, and decrease the levels of calcium in blood serum except female rats at the 12th week. Effects of Sr 2+ on body weight, body length, AKP activity of serum, calcium content of urine and breaking load of bended femur for rats were not found. However, there are differences in the effects of strontium on growth and development of bone between male and female rats. At the 12th week the content of calcium in blood serum decreased in male rats but increased in female rats in exposed groups. At the 4th and 8th weeks, urine Hop/Cr in male rats increased but it remained normal level in female rats. Sr 2+ increased the bone density of mixilla in male rats but it did not increase that of femur in female rats .It is suggested that such changes may be a result of the differences in endocritic regulation and metabolic process between two sexes.

关 键 词：锶 骨骼 牙齿 血清 骨密度 饮水 

分 类 号：X503.22[环境科学与工程—环境工程] R－322[医药卫生]