砷对大鼠生育繁殖及子代发育影响的研究  

The Effect of Arsenic on Reproduction and Offspring Development of Rats

作　　者：张晨[1] 姚华[1] 凌冰 刘继文[1] 刘开泰[1] 

机构地区：[1]新疆医学院预防医学系

出　　处：《卫生研究》1997年第3期179-182,共4页Journal of Hygiene Research

基　　金：国家自然科学基金

摘　　要：选用Ｗｉｓｔａｒ大鼠，以三氧化二砷为受试物，高剂量组约为１／１０ＬＤ５０。采用两代一窝繁殖法观察砷的生殖毒性和子代发育的变化。结果显示两代大鼠的受孕率和哺育成活率高剂量组明显低于对照组和低剂量组；而正常分娩率和幼仔出生存活率各组间无显著性差异；仔鼠体砷含量随染砷剂量的增加而逐渐增加，各组间比较均有显著性差异。仔鼠出生第１０，２０，３０天的体重高剂量组明显低于对照组和其它剂量组，具有显著性差异。说明砷可影响动物的生殖能力，并且通过哺乳使幼鼠接触到过量的砷而危及其生命。砷可以通过胎盘屏障而影响子代的生长发育。The effect of arsenic on reproduction and offspring development of Wistar rats was studied. The results demonstrated that the pregnant rate and feeding survival rate in high dose group were lower than these of in the groups of control and low dose. The differences of normal parturition rate and the survival rate in all the groups were not significant. The contents of arsenic in the young rats were increased by the doses of arsenic and the differences were significant. After 10, 20 and 30 days of birth, the weight of offspring in high dose group was lighter than that in the groups of control and low dose. According to the results, arsenic can affect the reproduction of rats and the development of their offspring.

关 键 词：砷 生育毒性 子代 发育 

分 类 号：X503.22[环境科学与工程—环境工程] R－322[医药卫生]