脾切除治疗小儿肝豆状核变性合并脾功能亢进的疗效分析  

Analysis of the therapeutic effect of splenectomy to treat hepatolenticular degeneration complicated with hypersplenism in children

作　　者：汪晓明[1] 张福忠[1] 于庆生[1] 侯勇[1] 沈瑜[1] 易维真[1] 

机构地区：[1]安徽中医学院第一附属医院普外科,安徽合肥230031

出　　处：《肝胆胰外科杂志》2007年第4期217-219,共3页Journal of Hepatopancreatobiliary Surgery

摘　　要：目的探讨脾切除治疗小儿肝豆状核变性合并脾功能亢进的有效性及安全性。方法回顾分析30例小儿肝豆状核变性合并脾功能亢进而行脾切除的临床资料,对手术前后血细胞和免疫球蛋白的变化进行比较。结果全部患者术后白细胞及血小板恢复至正常,手术前后免疫球蛋白比较差异无统计学意义。结论脾切除是小儿肝豆状核变性合并脾功能亢进的主要治疗措施,它能保证患儿继续驱铜治疗。只要充分地进行围手术期处理,脾切除是有效的、可行的、安全的。Objective To evaluate the efficacy and safety of spenectomy for the treatment of children with hepatolenticular degeneration combined with hypersplenism. Methods The clinical data of splenectomy for the treatment of children with hepatolenticular degeneration complicated with hypersplenism were analyzed retro- spectively. The comparison was made on the changes of blood cell and pre- and post-opertive immunoglobulin. Results Blood platelet and leucocyte count were increased significantly after operation in all 30 cases. Immunoglobulin pre- and post-operative was no significantly different. Conclusion Splenectomy is valuable in treating children with hepatolenticular degeneration complicated with hypersplenism. It is effective, safe and feasible. It can ensure the copper elimination therapy to continue.

关 键 词：肝豆状核变性 脾功能亢进 脾切除 

分 类 号：R742.4[医药卫生—神经病学与精神病学] R726.5[医药卫生—临床医学]