阿尔茨海默病患者空腹血糖、真胰岛素、C肽及β淀粉样蛋白的水平  

Level of Fasting Plasma Glucose, True Insulin, C-peptide and Amyloid Beta-protein in Patients with Alzheimer Disease

作　　者：刘卫刚[1] 田瑞振[1] 冯亚青[1] 赵大卫[1] 郭振华[1] 王建华[1] 刘桂芳[1] 哈志远[1] 

机构地区：[1]河北省人民医院老年神经科,河北石家庄市050051

出　　处：《中国康复理论与实践》2007年第7期645-646,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：2006年河北省科技厅指导计划(No.062761209)。

摘　　要：目的探讨阿尔茨海默病(AD)患者胰岛素及β淀粉样蛋白(Aβ)的异常代谢。方法随机选取70名正常人(对照组)、55例AD患者,检验其空腹血糖、真胰岛素、C肽、Aβ40、Aβ42水平。将AD患者按痴呆轻、中重度分组后与对照组进行比较。结果对照组比较,AD患者各组空腹血糖无显著性差异(P>0.05),中重度组真胰岛素和C肽升高(P<0.05),中重度组Aβ40升高(P<0.05),轻度组Aβ42明显升高(P<0.01)。结论AD患者体内存在胰岛素及β淀粉样蛋白代谢异常,其特征与痴呆的严重程度有关。Objective To investigate the level of insulin and amyloid beta-protein （Aβ） in patients with Alzheimer disease（AD）. Methods The levels of fasting plasma glucose, true insulin, C peptide, Aβ40 and Aβ42 in 70 healthy age-matched adults and 55 patients with AD were measured and analyzed. Results No differences were observed for the levels of fasting plasma glucose between AD groups and normal group （P〉0.05）. The level of the true insulin and C-peptide of the moderate/severe AD group were significantly higher than that of the normal control group（P〈0.05）, as well aw that of the Aβ40 （P〈0.05）. The level of Aβ42 of the mild AD group waw significantly higher than that of the normal control group（P〈0.01）. Conclusion Plasma insulin and Aβ are abnormal in AD, and they are related to severity of dementia.

关 键 词：阿尔茨海默病 胰岛素 Β淀粉样蛋白 

分 类 号：R749.1[医药卫生—神经病学与精神病学]