大黄丹参对重症急性胰腺炎患者血清TNF-α、IL-10影响的临床研究  

Effect of Rhubarb, Dan-shen Injection on serum TNF-α and IL-10 levels in patients with severe acute pancreatitis

作　　者：郭莲怡[1] 卢艳云[1] 

机构地区：[1]辽宁医学院附属第一医院消化科,辽宁锦州121001

出　　处：《中国现代医学杂志》2007年第13期1612-1614,共3页China Journal of Modern Medicine

摘　　要：目的观察大黄、丹参对重症急性胰腺炎(SAP)时血清肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)的影响及其对SAP的治疗作用及机制。方法将43例SAP患者随机分为治疗组和对照组,治疗组在西医综合治疗基础上加用大黄及丹参注射液,对照组仅采用西医综合治疗。检测治疗前及治疗后10d两组血清TNF-α、IL-10水平,并评价两组的治疗有效率;白细胞、血淀粉酶恢复时间;腹痛缓解时间及平均住院时间。结果治疗后治疗组白细胞、血淀粉酶恢复正常时间,腹痛缓解时间及平均住院时间较对照组明显缩短(P<0.01)。两组TNF-α水平较治疗前明显下降(P<0.01);IL-10水平较治疗前明显增高(P<0.01),而治疗组较对照组变化更明显(P<0.01)。结论大黄、丹参能抑制TNF-α分泌,上调IL-10水平,对SAP具有良好的治疗作用。[Objective] To investigate the effect of Rhubarb, Dan-shen injection levels on serum TNF-α and IL- 10 in patients with severe acute pancreatitis （SAP） and mechanisms. [Methods] 43 patients with SAP were randomly divided into 2 groups. Treated group were treated by general medicine and Rhubarb, Dan-shen injection. Control group were generally treated. Serum TNF-α and IL-10 were determined before and after therapy 10 days. To evaluate effective rate, time of white blood cell and serum amylase recovery, time of abdominal symptom and average hospital stay. [Result] Compared to control group, time of white blood cell and serum amylase recovery, time of abdominal symptom and average hospital stay in treated group were shorter significantly （P 〈0.01）. Compared to before treated, in both of the two groups, the levels of serum TNF-α decreased significantly, IL-10 increased significantly after treating （P 〈0.01）, but changes of treated group were more significant （P 〈0.01）. [Conclusion] Rhubarb, Danshen injection can inhabit TNF-α and increases IL-10, and have favorable treatment effect on patients with SAP.

关 键 词：重症急性胰腺炎 血清肿瘤坏死因子-Α 白细胞介素-10 大黄 丹参注射液 

分 类 号：R576[医药卫生—消化系统]