肿瘤分子流行病学与肿瘤标志物  

Cancer molecular epidemiology and tumor markers

作　　者：李文庆[1] 张联[1] 

机构地区：[1]北京大学临床肿瘤学院北京肿瘤医院北京市肿瘤防治研究所流行病学室,北京100036

出　　处：《基础医学与临床》2007年第7期729-738,共10页Basic and Clinical Medicine

摘　　要：肿瘤分子流行病学应用流行病学方法研究肿瘤标志物在高危人群和癌症患者中的分布和影响因素,对机体致癌物质暴露、生物学效应以及个体遗传易感性进行测量和评价,试图打开肿瘤病因"黑箱",揭示肿瘤发病的本质,它对肿瘤标志物的研究涉及病因学、预防医学和临床治疗各个领域。肿瘤分子流行病学要严格设计和实施,用质量控制原则、循证医学原则和伦理学原则指导肿瘤标志物的研究和应用。随着蛋白质组学等新兴学科的加入,结合了多学科优势的肿瘤分子流行病学正在迅速发展之中。Cancer molecular epidemiology focus on distribution and pathogenesis of tumor markers in high-risk populations and cancer patients. Cancer molecular epidemiology tries to open the ＂black box＂ and to elucidate the nature of cancer through the measurement and evaluation of exposure and response to carcinogens and individual genetic susceptibility, involving the fields of etiology, preventive medicine and clinical medicine. We need rigorously strengthen the design and implementation of cancer molecular epidemiology, the research and application of TM should enhance the principles of quality, evidence and ethics. With the utility of new subject tools such as proteomics, cancer molecular epidemiology which combines the advantages of multi-subjects is now quickly changing.

关 键 词：肿瘤分子流行病学 肿瘤标志物 

分 类 号：R73-31[医药卫生—肿瘤]