PSA、PSAD诊断前列腺癌的临床意义  

PSA and PSAD in the diagnosis of prostatic cancer

作　　者：刘庆鑫[1,2,3] 李胜文[1,2,3] 鲁学军 张志宏 孔祥林[1,2,3] 王文波[1,2,3] 肖连升 

机构地区：[1]解放军第二零八医院泌尿科 [2]白求恩医科大学 [3]中日联谊医院泌尿科

出　　处：《中华泌尿外科杂志》1997年第7期411-413,共3页Chinese Journal of Urology

摘　　要：采用放射免疫分析方法测定２０例前腺癌病人的血清前列腺特异抗原（ＰＳＡ）和前列腺特异抗原密度（ＰＳＡＤ），以３８例前列腺增生症作为对照，评价二者对前列腺癌的诊断价值，探讨其与临床分期和病理分级的关系。结果ＰＳＡ界限值定为４μｇ／Ｌ时，其诊断敏感度为８５．０％，特异度为３９．５％，准确度为５５．２％。ＰＳＡ界限值为１０μｇ／Ｌ时，敏感度８０．０％，特异度７６．３％，准确度为７７．６％。用ＰＳＡＤ诊断前列腺癌，敏感度为８５．０％，特异度为７８．９％，准确度为８１．０％。结果显示ＰＳＡＤ可更有效地诊断前列腺癌。ＰＳＡ与临床分期成正相关，而ＰＳＡＤ与临床分期成负相关。ＰＳＡ与病理分级有一定关系。Serum prostate specific antigen (PSA) and prostate specific antigen density (PSAD) by means of radioimmunoassay were assayed in 20 prostatic carcinoma patients (PCa) and in 38 benign prostatic hyperplasia as controls.When the upper normal limit of PSA was set at 4μg/L,the diagnostic sensitivity was 85.0% ,the specificity 39.5% and the accuracy 55.2%.If the upper normal limit of PSA was set at 10μg/L,the sensitivity,specificity and the accuracy was 80.0%,76.3% and 77.6% respectively.The diagnostic sensitivity of PSAD was 85.0%,the specificity 78.9% and the accuracy 81.0%.PSA was positively related to the clinical stage of the tumor while PSAD was negatively related.PSAD was believed to be more useful as a tumor marker for PCa.

关 键 词：前列腺肿瘤 特异性抗原 密度 免疫诊断 

分 类 号：R737.250.4[医药卫生—肿瘤] R730.45[医药卫生—临床医学]