乳腺癌激素受体、CerbB-2、P53、nm23基因的表达及与临床病理特征的关系  

Expression of ER,PR,C-erbB-2,P53,nm23 in Breast Carcinoma and Their Relationships with Clinicopathology

作　　者：胡江辉[1] 赵文健[1] 谢开红[2] 刘保安[3] 

机构地区：[1]湘南学院,湖南郴州423000 [2]湘南学院附属医院,湖南郴州423000 [3]中南大学湘雅医学院,湖南长沙410008

出　　处：《实用医技杂志》2007年第19期2531-2533,共3页Journal of Practical Medical Techniques

摘　　要：目的:探讨雌激素受体(ER)、孕激素受体(PR)及C-erbB-2、P53、nm23基因在乳腺癌组织中的表达及其与临床病理特征之间的关系。方法:用免疫组织化学S-P法检测113例乳腺癌组织中ER、PR及C-erbB-2、P53、nm23的表达。并结合乳腺癌临床病理特征进行分析。结果:113例乳腺癌组织中ER、PR及C-erbB-2、P53、nm23阳性表达率分别为49.6%、39.8%、59.3%、40.7%和71.7%,与临床分期、肿瘤大小、病理类型、年龄无关(P>0.05);C-erbB-2、P53阳性表达率与腋淋巴结转移呈正相关(P<0.05)。nm23阳性表达率与腋淋巴结转移呈负相关(P<0.05)。ER和(或)PR、nm23阳性组乳腺癌复发率低于阴性组(P<0.05)。C-erbB-2、p53阳性组乳腺癌复发率高于阴性组(P<0.05)。C-erbB-2的表达在ER、PR阴性组高于阳性组(P<0.05)。结论:联合检测ER、PR与C-erbB-2、P53、nm23表达对判断乳腺癌的预后、指导临床治疗具有十分重要的意义。Objective To explore expressions of ER, PR , C-erbB-2,p53,nm23 in breast carcinoma and their relationships with clinicopathology.Methods The expression of ER, PR, C-erbB-2,P53 and rim23 was detected by S-P immtmohistochemical method in 113 cases of breast carcinoma,and their relationship with clinicopathology was analysed.Results Positive expression rates of ER,PR, C-erbB-2,P53 and nm23 were 49.6% .39.8% .59.3% .40.7% and 71.7% respectively,There was no correlation between the positive expressions of ER.PR.C-erbB-2,p53 and rim23 with clinical staging,tumor diameter,histological types and patient age （P 〉0.05）. The expressions of C-erbB-2 and p53 were correlated positively with lymph node metastasis （P〈0.05 ）.The expression of rim23 was correlated negatively with lymph node metastasis （P〈 0.05 ）. The recurrence rates of the carcinomas with positive expression of ER/PR and nm23 were lower than those with negative expression （P〈 0.05 ）,On the contrary,the relapse rates of the carcinomas with positive expression of C-erbB-2 and p53 were superior to those with negative expression （P〈0.05）, The positive expression rate of C-erbB-2 was higher in the group with positive expression of ER and PR than negative group （P〈0.05）,Conclusion Combined detection of the expression of ER, PR, C-erbB-2,P53 and nm23 in breast carcinoma tissue play a important role in judging prognosis and guiding clinical treatment.

关 键 词：乳腺癌 雌激素受体 孕激素受体 C-ERBB-2 P53 NM23 基因 

分 类 号：R737.9[医药卫生—肿瘤]