射频消融术和手术对原发性肝癌体内细胞免疫状态变化的影响  

Influence of radio frequency ablation and surgical resection of primary hepatocellular carcinoma on the change of cellular immunity

作　　者：卢传辉[1] 尤俊[1] 刘静[2] 洪明[1] 许林[1] 张志明[1] 

机构地区：[1]福建医科大学附属厦门第一医院肿瘤外科,福建厦门361003 [2]福建医科大学附属厦门第一医院B超室,福建厦门361003

出　　处：《中华肿瘤防治杂志》2007年第15期1146-1148,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：厦门市科技基金资助项目(3502Z20052025)

摘　　要：目的:探讨射频消融与手术治疗原发性肝癌对患者外周血T淋巴细胞亚群的影响。方法:46例原发性肝癌患者(射频消融组26例,手术治疗组20例),应用流式细胞仪检测两组患者外周血T淋巴细胞亚群的变化。结果:射频消融组治疗10d后与治疗前T淋巴细胞亚群比较,CD3+、CD4+T细胞计数上升,CD8+T细胞计数下降,CD4+/CD8+上升,差异有统计学意义,P<0.01;手术治疗组术后CD3+、CD4+T细胞计数下降,CD4+/CD8+下降,差异有统计学意义,P<0.05。结论:射频消融治疗原发性肝癌,治疗后免疫抑制状态改善,细胞免疫功能增强,而手术治疗肝癌,术后细胞免疫功能明显下降。To study the influence of radio frequency ablation and surgical resection of primary hepatocellular car cinoma on T lymphocyte subsets in the peripheral blood. METHODS： Forty-six patients were divided into two groups with 26 treated by radio frequency ablation and 20 by surgical resection. T lymphocytes in the peripheral blood of patients in the two groups were assayed by flow cytonetry and the results were compared. RESULTS： After 10 days of the treatment, CD3^＋ and CD4 T lymphocyte of the radio frequency ablation group increased, CD8 T lymphocyte decreased, CD4^＋/CD8^＋ increased, and the difference was significant, P〈0.01 ; CD3^＋ and CD4^＋ T lymphocyte of the surgical resection group decreased, CD4^＋/CD8^＋ decreased, and the difference was also significant, P〈0. 05. CONCLUSION： Radio frequency ablation improves the immune suppression and enhances the cellular immune function, while surgical resection decreases the cellular immune function.

关 键 词：导管消融术 肝肿瘤/外科学 T淋巴细胞亚群 治疗结果 

分 类 号：R735.7[医药卫生—肿瘤]