Syk蛋白在胰腺癌组织中的表达及临床意义  

Expression of Syk in pancreatic cancer and its clinical significance

作　　者：宋玉琴 周武元[2] 赵文华[2] 张波[2] 于文胜[2] 吕丽红[3] 仲伟霞[2] 李胜[2] 

机构地区：[1]北京市肿瘤防治研究所北京肿瘤医院血液肿瘤科,北京100036 [2]山东省肿瘤防治研究院肝胆外科,山东济南250117 [3]山东大学医学院手术学教研室,山东济南250012

出　　处：《中华肿瘤防治杂志》2007年第15期1149-1151,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金(30571712);山东省中青年科学家科技奖励基金(2005BS03003);山东省医药卫生科研项目(2005HW133)

摘　　要：目的:探讨胰腺癌组织中Syk蛋白的表达及临床意义。方法:应用免疫组化技术检测胰腺癌组织中Syk蛋白的表达情况。结果:正常胰腺组织表达Syk蛋白,在慢性胰腺炎组织中有中等表达,其阳性率分别为100.0%和77.8%;在胰腺癌组织中阳性率为27.5%,大多数呈中等或弱阳性表达,与前两者比较差异均有统计学意义,P值分别为0.0002和0.0079;Syk蛋白与肿瘤的发生部位、分化程度和有无转移灶之间差异无统计学意义;与TNM分期有关,Ⅰ+Ⅱ期组表达明显高于Ⅲ+Ⅳ组期(P=0.0245)。结论:Syk蛋白在胰腺癌组织中低表达与胰腺癌的发生、发展有关。To investigate the expression of Syk in pancreatic cancer and its clinical significance. METHODS： The expression of Syk was assayed by means of immunohistochemistry. RESULTS： The positive rates of Syk were 27.5%, 77.8% and 100.0%, in pancreatic cancer, chronic inflammtion and normal tissues respectively. The expression of Syk in pan- creatic cancer was significantely lower than that in other two kinds of tissues, P was 0.00 and 0. 007 9 respectively. There was no correlation between the expression of Syk and the site, differentiation, metastasis. Expressions of Syk of were higher I—Ⅱ stages than those of Ill-IV stages of pancreatic cancer. CONCLUSIONS..Syk is related to the development of pancreatic

关 键 词：胰腺肿瘤 免疫组织化学 对比研究 

分 类 号：R735.9[医药卫生—肿瘤]