血浆置换术联合化疗治疗多发性骨髓瘤疗效观察  

Therapeutic observation of the plasma exchange combination chemotherapy for multiple myeloma

作　　者：翁巍[1] 陈健军[1] 孙致信[1] 

机构地区：[1]上海市长宁区中心医院血液内科,200336

出　　处：《淮海医药》2007年第5期403-404,共2页Journal of Huaihai Medicine

摘　　要：目的了解血浆置换术联合化疗对降低多发性骨髓瘤(MM)异常免疫球蛋白的作用与疗效。方法血浆置换组25例,采用CobeSpectra血细胞分离机行血浆置换(PE)术联合化疗治疗,对照组20例采用化疗,比较2组病例治疗前后球蛋白(GLB),血沉(ESR),肌酐(CR)下降情况、临床症状缓解效果及疗效。结果血浆置换术联合化疗组治疗前后GLB,ESR,CR下降有统计学意义(P<0.05),临床症状缓解,肾功能改善,但2组疗效比较差异无显著性(P>0.05)。结论血浆置换术联合化疗组能迅速降低GLB,ESR,CR,具有明显改善临床症状和肾功能的优点,但总有效率无明显优势。Objective To comprehend the effect of declining the abnormal immunoglobulin and therapeutic effects of the plasma exchange （PE） combination chemotherapy for multiple myeloma （MM）. Mechods The plasma exchange combination was conducted with CobeSpectra blood cells separator in 25 cases with MM. A control group of 20 cases was treatd with chemotherapy only. The declining state of globulin（GLB）, blood sedimentation rate（ESR） ,creatinine （CR）,and the relief effect of the clinical symptom and therapeutic effect were compared before and after the treatment. Results Degression of the GLB,the ESR and the CR showed statistical significance（P〈0. 05）. Clinical symptom was obviously relieved. Renal function was improved. The therapeutic effect of the two groups didn＇t indicate statistical significance （P〉0. 05）. Conclusion The plasma exchange combination chemotherapy has the advantages of improving clinical symptoms and renal function significantly in the cases suffering MM. But it has no obvious ascendancy in total effective rate.

关 键 词：多发性骨髓瘤 血浆置换术联合化疗 治疗结果 

分 类 号：R733.3[医药卫生—肿瘤]