瘦素基因G2548A位点多态性与男性高尿酸血症的相关性研究  

Study on the association of leptin gene polymorphisms G2548A with hyperuricemia among males and analysis

作　　者：江艳[1] 姚华[2] 孙玉萍[3] 王秋云[4] 胡静[4] 古丽巴哈.阿不都热合曼 妥玲[4] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830000 [2]新疆医科大学中医学院,新疆乌鲁木齐830000 [3]新疆医科大学基础医学院,新疆乌鲁木齐830000 [4]新疆医科大学附属中医医院,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2007年第6期547-550,共4页Journal of Xinjiang Medical University

基　　金：教育部高等学校博士点科研基金项目(20060760002);新疆高校创新群体科研基金(XJEDV200GO9)

摘　　要：目的:观察瘦素基因启动子区第2548位核苷酸G→A变异与汉族男性原发性高尿酸血症的关系。方法:将321例男性体检者分为高尿酸血症组(145例)与对照组(176例),进行瘦素基因多态性的检验,同时进行血浆瘦素水平、人体测量学、代谢、临床参数的检测。结果:高尿酸血症组和对照组瘦素基因G2548A位点不同基因型的分布差异有统计学意义,携带A等位基因的频率明显高于对照组(χ2=17.313,P<0.01),瘦素基因的G/G、A/G、A/A各基因型的血尿酸(SUA)、胰岛素浓度(INS)、HOMA-IR及瘦素(LEP)水平呈依次上升趋势,其中A/A基因型与G/G基因型的差异有统计学意义(P<0.05)。结论:高尿酸血症患者的瘦素基因G2548A多态性与空腹血浆瘦素水平、胰岛素浓度、血尿酸水平相关。A等位基因可能是原发性高尿酸血症(HUM)发病的遗传易感因素。Objective： To explore whether single nucleotide polymorphism G/A in the promoter of leptin gene related to hyperuricemia in Chinese Han peoples of Urumqi city. Methods： The genotypes of leptin were detected by the methods of polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） in 145 hyperuricemia patients and 176 controls. Leptin, body common items and biochemical variable were measured. Results. There was significance difference in frequencies of allele in G2548A polymorphism between hyperuricemia and control group （χ^2 =17. 313, P 〈0.01）. Individuals with AA genotype showed higher fasting leptin, INS, HOMA- IR than those with GG genotype （P 〈0.05）. Conclusion： The G2548A polymorphism in leptin gene is associated with fasting leptin in patients with hyperuricemia. Anallele of leptin may be a genetic factor that may contribute to individual susceptibility for hyperuricemia.

关 键 词：多态性 原发性高尿酸血症 瘦素 相关性 

分 类 号：R-34[医药卫生] R696