鼻腔NK/T细胞淋巴瘤预后相关因素分析  

Prognostic factors of nasal NK/T-cell lymphoma

作　　者：徐刚[1] 王槐富[1] 杜泽秀[1] 何刚[1] 

机构地区：[1]四川省医学科学院,四川省人民医院耳鼻咽喉科,四川成都610072

出　　处：《中国耳鼻咽喉头颈外科》2007年第7期393-396,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的探讨血液学常规检测在鼻腔NK/T细胞淋巴瘤预后分析中的应用。方法收集62例鼻腔NK/T细胞淋巴瘤患者的临床病理资料,并进行随访。对患者血液乳酸脱氢酶(lactic acid dehydrogenase,LDH)、球蛋白、白蛋白、血红蛋白(hemoglobin,Hb)和白细胞数等指标进行检测。鼻腔NK/T细胞淋巴瘤患者预后的影响因素采用单因素分析和Cox比例风险模型多因素分析。结果62例患者中,男女比例约为3:1,患者中位年龄41岁。92%的患者为AnnArborⅠ～Ⅱ期,76%的患者属于国际预后指数(international prognostic index,IPI)低危组。治疗前身体状况评分(performance status,PS)0～1分的患者占总数的92%,贫血见于26%的患者,而53%的患者伴随有B症状。全组患者中位生存时间27个月(95%CI:10～45个月)。单因素分析显示,性别、年龄、PS评分、LDH水平、IPI、B症状、Hb浓度及白细胞数等指标与预后相关。多因素分析显示,治疗前Hb<110g/L,有B症状及PS评分>1是鼻腔NK/T细胞淋巴瘤患者的不良预后因素。结论Hb浓度、B症状及PS评分可以作为判断鼻腔NK/T细胞淋巴瘤预后的参考因素。To investigate the application of blood test in the prognosis of nasal NK/T-cell lymphoma. METHODS The clinicopathologic and follow-up data of 62 patients with nasal NK/T-cell lymphoma proven by pathological examination were collected. The blood lactic dehydrogenase（LDH）, globulin（GLB）, albumin（ALB）, hemoglobin（Hb）, and white blood cell（WBC） were examined in these patients. The correlation between these factors and prognosis were analyzed with univariate analysis and multivariate analysis. RESULTS Of the 62 patients, 47 were males and 15 were females. Their median age was 42 years. Ninety two percent of the patients were in Ann Arbor 1/11 stage, and 76 % had international prognostic index（IPI） of 0 or 1. Before treatment, 92 % of the patients had ECOG performance status（PS） score of 0-1, 26 % had anemia, 53 % presented B symptoms. The median overall survival time was 27 months （95 % Ch 10-45months）. In univariate analysis, gender, age, PS score, LDH, IPI, B symptoms, Hb and WBC were statistically significantly correlated to the prognosis. In multivariate analysis, Hb〈110 g/L, B symptoms, and ECOG PS score〉l were statistically significant unfavorable prognostic factors. CONCLUSION Hb together with B symptoms and PS score may be independent prognostic factors for nasal NK/T cell lymphoma.

关 键 词：淋巴瘤 非霍奇金 鼻腔 预后 血红蛋白类 乳酸脱氢酶类 

分 类 号：R739.62[医药卫生—肿瘤]