性别、年龄因素对人肺组织DNA加合物形成量影响的探讨  

The Effects of Sex and Age on DNA Adduct Formation in Human Lung Tissue

作　　者：杨柯[1,2] 崔涛[1,2] 吕京[1,2] 孟庆海[1,2] 张海青[1,2] 赵志文[1,2] 谢汇江 贺锡雯[1,2] 

机构地区：[1]中国预防医学科学院劳动卫生职业病研究所 [2]北京市结核病胸部肿瘤研究所

出　　处：《卫生研究》1997年第1期2-5,共4页Journal of Hygiene Research

基　　金：国家自然科学基金

摘　　要：探讨了ＤＮＡ加合物的量在人肺组织中随年龄、性别的分布。实验结果表明：年龄与肺组织中ＤＮＡ加合物的相关系数很低，不同年龄组ＤＮＡ加合物的平均相对加合物标记（ＲＡＬ）值无显著性差异。男性肺组织中ＤＮＡ加合物的量显著高于女性（Ｐ＜０．０５），除与吸烟因素有关外，男女肺组织中ＤＮＡ加合物量的差异也不能排除内分泌因素的影响。In order to evaluate the roles of sex and age in the formation of lung tissue DNA adducts, the levels of DNA adducts in human lung tissues from both patients with or without lung cancer were examined. The results showed there was a low correlation coefficient ( r =0 11) between age and DNA adducts, but a significant difference in sex being observed. Smoking is a strong factor in the formation of DNA adducts. However, The role of endocrine can not be ruled out.

关 键 词：肺癌 DNA加合物 性别 年龄 

分 类 号：R734.202[医药卫生—肿瘤]