骨巨细胞瘤的性质和分级  

The Biological Nature and Pathological Grading of Giant Cell Tumour of Bone

作　　者：应明 沈晓秋 赵红军 

机构地区：[1]解放军第八一医院骨科,210002

出　　处：《江苏医药》1997年第3期158-160,共3页Jiangsu Medical Journal

摘　　要：对32例骨巨细胞瘤的核DNA含量行流式细胞分析，以探讨该肿瘤的性质和分级。结果表明：Ⅰ级骨巨细胞瘤仍可看作是良性肿瘤，大多数DNA倍体水平正常；Ⅱ级骨巨细胞瘤有明确的恶性倾向，约三分之一的肿瘤DNA倍体水平异常；Ⅲ级骨巨细胞瘤则是恶性肿瘤，大部分肿瘤DNA倍体水平异常。另外，病理分级与肿瘤的S期细胞百分数及增殖细胞指数也有一定相关性，Ⅲ级骨巨细胞瘤有更大的细胞增殖活性。The biological nature and pathological grading of giant cell tumour of bone (GCT) was studied by the nuclear DNA content flow cytometry in a group of 32 cases. The results shown：on the point of DNA content,grade I GCT was seen as a kind of benign tumour because most of them had a normal DNA content. And grade Ⅱ GCT had an obvious malignancy tendency due to one third of this grade tumour were aneodiplody. Since many grade Ⅲ GCT had abnormal DNA content, it could be considered as a malignant tumour. Furthermore there were some correlation between the pathological grading and S-phase cell percentage, proliferating index as provided by flow cytometry. The grade Ⅲ GCT had the highest cell proliferating activity.

关 键 词：巨细胞瘤 骨肿瘤 流式细胞分析 病理分级 

分 类 号：R738.102[医药卫生—肿瘤]