丁基苯酞对局部脑缺血大鼠记忆障碍的影响  

Effect of dl 3 n butylphthalide on memory disturbance induced by focal cerebral ischemia in rats

作　　者：胡盾[1] 张丽英[1] 冯亦璞[1] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所

出　　处：《中国药理学与毒理学杂志》1997年第1期14-16,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：观察了丁基苯酞（ＮＢＰ）对局部脑缺血大鼠记忆障碍的影响．用穿梭箱进行学习记忆获得性训练，以主动回避反应潜伏期和次数以及逃避反应潜伏期为指标，评价大脑中动脉阻断（ＭＣＡＯ）后记忆保持的能力．结果表明：假手术组的记忆功能与正常组没有显著差别，而缺血对照组大鼠主动回避反应次数减少６０％，主动回避和逃避反应潜伏期分别较缺血前延长４．２±１．６和４．１±３．３ｓ．给ＮＢＰ３０和１００ｍｇｋｇ－１后主动回避反应的次数明显提高，主动回避反应潜伏期明显缩短，与缺血对照组比较均有非常明显的差别．表明ＮＢＰ对局部脑缺血引起的记忆障碍有明显改善作用．Effect of dl 3 n butylphthalide (NBP) on response for shuttle box was studied in rats subjected to middle cerebral artery occlusion (MCAO). Each rat was subjected to 20 trials per time for 4-5 times (one time every second day). A buzzer for 10 s was used as conditioning stimulus followed by a foot shock for 10 s as unconditioning stimulus . The error number of active avoidance response and the latencies of active avoidance and escape response were observed. NBP was given ig 15 min after MCAO. The experiment was carried out 24 h after MCAO. The result indicated that no change was found in the sham operation group before and after MCAO. However the number of the active avoidance responsewasdecreasedfrom16.7±2.9to6.5± 5.0, the latencies of active avoidance and escape response were prolonged by 4.2±1.6 and 4.1± 3.3 s after MCAO in vehicle group. The number of active avoidance response was significantly increased and the latencies of active avoidance and escape response were shortened markedly after receiving NBP 30 and 100 mg·kg 1 respectively. The results suggest that NBP has an ameliorative effect on memory disturbance induced by focal cerebral ischemia in rats.

关 键 词：丁基苯酞 脑缺血 记忆障碍 

分 类 号：R743.310.6[医药卫生—神经病学与精神病学] R749.790.5[医药卫生—临床医学]