血小板膜糖蛋白GP Ⅲ a基因多态性与脑血栓关系的研究  

Relationship between the Polymorphism of Platelet Membrane Glycoprotein GP Ⅲ a and Cerebral Thrombosis

作　　者：刘彦虹[1] 安晶红[1] 牟凤云[1] 

机构地区：[1]黑龙江中医药大学博士后科研流动站,黑龙江哈尔滨150040

出　　处：《中国血液流变学杂志》2007年第2期185-187,共3页Chinese Journal of Hemorheology

基　　金：黑龙江省科技厅攻关项目(GB06C40303)

摘　　要：目的探讨我国北方地区人群血小板膜糖蛋白GPⅢa基因多态性与脑血栓的关系。方法运用聚合酶链反应-限制性片断长度多态性分析(PCR-RELP)技术检测100例脑血栓患者及100例健康对照者GPⅢa的P1A的多态性。结果所有患者和健康对照者均为PIA1/A1基因型,PIA2基因型的检出率为0%。结论我国北方地区人群血小板膜糖蛋白GPⅢa基因多态性与脑血栓的发生无相关性。Objective To explore the relation between platelet membrane glycoprotein GPⅢ a gene polymorphism and cerebral thrombosis of people in the north of our country.Methods To detect GPⅢ a P1^A polymorphism in 100 cerebral thrombosis patients and 100 healthy collators with polymerase chain reaction restriction fragment length polymorphism（PCR-RELP）technique.Results Genotype in both cerebral thrombosis patients and healthy collators is PI^A1/A1.Rate of PI^A2 genotype is 0 %.Conclusions Platelet membrane glycoprotein GPⅢ a gene polymorphism and cerebral thrombosis morbidity is independent in people in the north of our country.

关 键 词：脑血栓 血小板膜糖蛋白 多态性 

分 类 号：R743.32[医药卫生—神经病学与精神病学]