急性大脑中动脉栓塞的动静脉联合溶栓治疗的实验研究  

Experimental Study on Combined Intravenous and Intra-arterial Thrombolysis in the Middle Cerebral Artery Occlusion

作　　者：戚观树[1] 王伟[1] 许茂盛[1] 侯群[1] 

机构地区：[1]浙江省中医院神经科,310006

出　　处：《中国临床神经科学》2007年第4期353-357,共5页Chinese Journal of Clinical Neurosciences

基　　金：浙江省卫生厅资助项目课题(2002A071)

摘　　要：目的:评价动静脉联合溶栓治疗实验兔急性脑梗死的疗效。方法:采用兔自体血栓栓塞大脑中动脉制成急性脑梗死模型,随机分为动、静脉联合溶栓组(IA+IV组)、静脉溶栓组(IV组)及对照组,分别给予以动脉+静脉、静脉内注射尿激酶及静脉内注射生理盐水。采用DSA观察血管再通率、核磁共振弥散成像观察相对表观系数(rADC)、改良Bederson评分法观察神经功能缺损。结果:IA+IV组血管再通率为83.3%、rADC值(0.918±0.144)及神经功能缺损评分(0.80±0.84)均优于IV组和对照组。结论:动静脉联合溶栓治疗急性脑梗死优于静脉内溶栓治疗。Aim ： To evaluate the efficacy of combined intravenous and intra-arterial thrombolysis in the rabbit middle cerebral artery occlusion model. Methods： The middle cerebral artery occlusion model（MCAO） was reproduced in New Zealand rabbit by autologous clot. The MCAO rabbits were randomly divided into combined intravenous and intra-arterial thrombolysis group （group IA＋ Ⅳ）, intravenous thrombolysis group （group Ⅳ） and control group （group C）. The rabbits of group of IA＋Ⅳ were given urokinase（UK） intravenously and intra-arterially, the rabbits of group Ⅳ were given UK intravenously only and the rabbits of group C were saline injection by vein. The repatence rate, relative-apparent diffusion coefficient （rADC） and the neurologic function deficit score were compared among them. Results： The repatence rate （ 83.3%）, rADC （ 0,918 ± 0.144） and the neurologic function deficit score of group IA＋ Ⅳ are better than group Ⅳ and group C. Conclusion： Combined intravenous and intra-arterial thrombolysis in the rabbit middle cerebral artery occlusion model is better than intravenous thrombolysis.

关 键 词：脑栓塞 溶栓治疗 核磁共振成像 弥散加权成像 数字减影血管造影 兔 

分 类 号：R743[医药卫生—神经病学与精神病学]