Syk与胃癌生物学行为的相关性研究  

Study on the correlation between Syk expression and biological behaviors in human gastric carcinoma

作　　者：袁士龙[1] 郭春良[2] 焦辉[3] 李端阳[1] 冯爱民[1] 丁永斌[4] 夏建国[4] 

机构地区：[1]武警江苏总队南京医院外一科,江苏南京210028 [2]武警医学院附属医院普外科,天津300162 [3]武警8664部队卫生队,新疆新源835807 [4]南京医科大学第一附属医院普外科,江苏南京210029

出　　处：《武警医学院学报》2007年第5期514-517,共4页Acta Academiae Medicinae CPAPF

摘　　要：【目的】探讨Syk在胃癌组织中的表达态势与胃癌生物学行为的相关关系。【方法】采用逆转录-聚合酶链反应(RT-PCR)和SP免疫组化技术,检测62例胃癌及癌旁组织中Syk表达状况,与胃癌病理组织学检查结果进行相关性统计分析。【结果】62例胃癌组织14/62(22.6%),癌旁胃组织54/62(87.1%)Syk表达阳性,两者Syk阳性表达率差异有显著性(χ2=51.6、P<0.05)。41例有淋巴结转移的胃癌,癌组织仅3例Syk蛋白表达阳性。21例无淋巴结转移的胃癌,癌组织11/21Syk表达阳性,两者Syk阳性表达率差异有极显著性(χ2=13.66、P<0.01)。Syk表达与胃癌患病年龄、性别、肿瘤大小、部位、浸润深度、肿瘤细胞病理分级均无相关性(P值均>0.05)。【结论】胃癌的发生和转移与Syk的表达缺陷密切相关。[Objective] To investigate the correlation between the expression of Syk and the biological behaviors in human gastric cancer. [Methods] Syk mRNA in the tissues of gastric tumor was detected by reverse transcription-polymerase chain reaction （RT-PCR）. The expression of protein Syk in 62 gastric cancer samples were detected by immunohistochemical technique, and analyzed in relation with clinicopathologic data of the patients. [Results] Of the 62 gastric cancer specimens, 14 were Syk positive, expression of Syk were detected in 54 out of 62 adjacent normal tissues. A significant difference was noted between two groups （χ2 = 51.6, P 〈 0.05）. Furthermore, only 3 gastric cancer tissues in 41 patients with lymph node metastasis had the Syk expression. Syk negative cancers were associated with more lymph node metastasis（χ2 = 13.66, P〈 0.01）. Syk expression was not associated with the patients＇ sex, age, tumor size, location and the degree of invasion and stages （ P 〉 0.05）. [Conelusionsl The expression of Syk may play an important role in the genesis and metastasis of gastric cancer.

关 键 词：Syk蛋白 胃癌 生物学行为 

分 类 号：R735.2[医药卫生—肿瘤]