实验性脊髓损伤铁蛋白表达的相关性研究  

The expression of ferritin after spinal cord injury:A relative study

作　　者：梁朝革[1] 贾连顺[2] 佐雪梅[3] 张亚东[1] 王奕[1] 汤阳[1] 

机构地区：[1]上海市长宁区中心医院骨科,上海200336 [2]上海长征医院骨科,200003 [3]上海市长宁区中心医院检验科

出　　处：《颈腰痛杂志》2007年第4期276-278,共3页The Journal of Cervicodynia and Lumbodynia

摘　　要：目的通过建立大鼠脊髓损伤模型,研究不同致伤力对铁蛋白表达的影响。方法分别通过0、25、50、75gcf的致伤力,观测伤后脊髓组织中游离铁、铁蛋白表达的变化,并对其进行相关分析、多元回归分析及变量筛选。结果伤后脊髓组织中游离铁、铁蛋白表达同致伤力成正相关,铁蛋白同游离铁成负相关。结论铁蛋白的表达同脊髓组织的损伤程度相关,并参与了脊髓继发损伤过程的调节作用。Objective To assess the effect of different force on the expression of ferritin in secondary lesion after SCI in rat. Mthods Contusion model of SCI using the modified Allen＇s method using different force（.,25,50,75gcf）were used. Four hours after trauma, Fe^2＋, activity of ferritin has been measured using Evans and Halliwell methods,immunohistochemistry methods in the lesion of spinal cord. Results There were significantly differences in Fe^2＋,activity of ferrtin in dif- ferent groups. Linear regression analysis revealed significant positive associations of ferritin and Fe^2＋ with hit force. Multiple linear regression analysis revealed significant associations of ferritin with Fe^2＋ and hit force. Conclusion Experimental demonstration the expression of ferritin is correlated with the degree of Fe^2＋ and hit force,but ferritin is correeated with Fe^2＋ in negative association. Possible implications for ferritin mediated secondary damage.

关 键 词：脊髓损伤 游离铁 铁蛋白 

分 类 号：R744.2[医药卫生—神经病学与精神病学] Q591.2[医药卫生—临床医学]