益生菌对炎症性肠病的治疗作用和机制  

Therapeutic effect and mechanism of probiotics on inflammatory bowel disease

作　　者：杨明[1] 韩真[1] 

机构地区：[1]皖南医学院弋矶山医院消化内科,安徽省芜湖市241000

出　　处：《世界华人消化杂志》2007年第14期1634-1638,共5页World Chinese Journal of Digestology

摘　　要：炎症性肠病包括溃疡性结肠炎和克罗恩病.炎症性肠病患者肠道内存在茵群失调,若给患者补充正常细菌即益生菌,使肠道内菌群失调得到纠正,可使病情缓解.益生菌能改变肠道菌群比例、转化某些肠内物质、提高肠上皮的屏障功能、防止肠细菌易位以及通过调节细胞因子减轻炎症.本文对益生菌以上作用及机制作一综述.Inflammatory bowel disease （IBD） includes ulcerative colitis （UC） and Crohn＇s disease （CD）. Many studies demonstrate an involvement of intestinal microflora in the pathogenesis of IBD. Tissue damages can result from dysregulated immune response to intestinal bacteria in genetically susceptible individuals. Therefore, alteration of the intestinal microflora may represent a feasible therapeutic approach for IBD. Probiotics can change the proportion of intestinal microflora, improve the function of intestinal epithelial barrier, prevent intestinal bacterial translocation and alleviate the inflammation degree. In this article, we reviewed the effect of probiotics in the treatments of IBD and its mechanism.

关 键 词：益生菌 炎症性肠病 肠道菌群 

分 类 号：R574[医药卫生—消化系统]