NERD患者埃索美拉唑联合莫沙必利与加强生活方式干预对照研究112例  

Efficacy of esomeprazole,mosapride and lifestyle enhancement in the treatment of non-erosive gastroesophageal reflux disease: an analysis of 58 cases and comparative study

作　　者：季代金[1] 黄茂涛[1] 余宁[1] 赵悦[1] 陈勇[1] 

机构地区：[1]中国人民解放军第452医院消化内科,四川省成都市610021

出　　处：《世界华人消化杂志》2007年第14期1650-1653,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨NERD患者在埃索美拉唑联合莫沙必利治疗的基础上,介入加强生活方式干预的疗效.方法:112例NERD患者分为对照组(n=54)和试验组(n=58).所有病例均采用埃索美拉唑(40 mg,qd)联合莫沙必利(5 mg,tid)治疗8 wk,实验组同时进行加强干预治疗,如生活方式调整、饮食调整、心理干预及运动调养等.采用X^2检验比较两组疗效.结果:实验组58例中显效42例,有效12例,无效4例,总有效率93.10%(54/58);对照组54例中显效26例,有效18例,无效10例,总有效率81.84%(44/54).两组比较具有显著的差异性(X^2=7.39,P<0.01).结论:在药物治疗控制症状的基础上,积极介入生活方式干预,加强了医患之间的沟通,能提高患者的依从性,可更有效地改善NERD患者的临床症状.AIM： To investigate the therapeutic effects of lifestyle enhancement on patients with non-erosive gastroesophageal reflux disease （NERD） based on the combined treatment of esomeprazole and mosapride.METHODS： A total of 112 NERD patients were divided into control group （n = 54） and test group （n = 58）. All the patients were given esomeprazole （40 rag, qd） and mosapride （5 rag, tid） for 8 weeks. Besides, the lifestyle in test group was enhanced （adjusting lifestyle, diet, mental status and movement intensity）. Chisquare test was conducted to compare the efficacy between the two groups. RESULTS： In the test group, notable efficacy was found in 42 cases, effectivity in 12 cases, and inefficacy in 4 cases and the total effective rate was 93.10% （54/58）. In the control group,notable efficacy was observed in 26 cases, effectivity in 18 cases, and inefficacy in 10 cases are ineffective, and the total effective rate was 81.84% （44/54）. There was significant difference between the two groups （2 = 7.39, P〈0.01）. CONCLUSION： On the basis of treatment by esomeprazole and mosapride, lifestyle enhancement can improve the compliance and clinical symptoms of NERD patients.

关 键 词：非糜烂性胃食管反流病 埃索美拉唑 莫沙 

分 类 号：R571[医药卫生—消化系统]