VEGF、CD_(44)V_6在乳腺癌组织中的表达及意义  

Expressions of VEGF and CD_(44)V_6 in Human Breast Cancer and Their Significance

作　　者：王清芬[1] 吴绍新[1] 官德元[1] 

机构地区：[1]荆门职业技术学院医学院病理学教研室,湖北荆门448000

出　　处：《实用临床医学（江西）》2007年第6期10-12,共3页Practical Clinical Medicine

摘　　要：目的:探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)及粘附分子CD44的变构体CD44V6在乳腺癌组织中的表达和其与淋巴转移和临床分期的关系。方法:应用免疫组化SP法检测53例乳腺癌组织中VEGF、CD44V6的表达水平。结果:53例乳腺癌组织中,VEGF、CD44V6的阳性表达率分别为79.2%(42/53)、64.2%(34/53);VEGF及CD44V6的表达与淋巴转移呈正相关(r分别为0.496、0.381,P均<0.05),而与临床分期也呈正相关(r分别为0.412、0.609,P均<0.05)。结论:VEGF、CD44V6在乳腺癌组织中的过度表达在乳腺癌的发生、发展中可能协同起作用,并可作为判断乳腺癌生物学行为的指标。Objective： To investigate the expressions of VEGF and CD44V6 in breast cancer tissues, and explore their correlation to lymphatic metastasis and different clinical TNM stage. Methods： The expressions of VEGF and CD44V6 in 53 samples of breast cancer tissues were detected by SP immunohistochemistry. Results： The positive rates of VEGF and CD44V6 in 53 samples of breast cancer were 79.2% and 64.2%. The positive rates of VEGF and CD44V6 were correlated with lymphatic metastasis （r was 0. 496and 0. 381）and clinical TNM stage（r was 0. 412 and 0. 609）, with significant difference （P〈0. 05）. Conclusion： The expressions of VEGF and CD44 V6 in breast cancer tissues may be cooperative effects in the occurrence and they could be used as an important biologic marker for breast cancer.

关 键 词：乳腺癌 VEGF CD44V6 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]