醒脑静与纳洛酮对严重乙醇中毒小鼠苏醒时间及其机制的实验研究  

The Effects and Potential Mechanism of Xingnaojing Combined Naloxone in Sobering Acute Alcohol Poisoning Rats up

作　　者：魏毅[1] 宋洁[2] 李湘华[2] 曾庆理[2] 杨倜[2] 张贵平[1] 

机构地区：[1]广州医学院药理教研室,广州市510182 [2]广州医学院第二附属医院

出　　处：《医学理论与实践》2007年第8期871-872,共2页The Journal of Medical Theory and Practice

摘　　要：目的:探讨醒脑静合用纳洛酮对严重乙醇中毒小鼠的治疗作用及可能机制。方法:腹腔注射白酒制作小鼠急性乙醇中毒模型,随机分为3组,分别给予生理盐水、纳洛酮、纳洛酮+醒脑静,记录苏醒时间并测量血中超氧化物歧化酶、丙二醛。结果:纳洛酮+醒脑静组苏醒时间明显快于生理盐水组和纳洛酮组(P<0.05),超氧化物歧化酶较纳洛酮组显著增加(P<0.05)。结论:醒脑静对酒精中毒小鼠有一定的治疗作用,其机制可能与抑制氧化损伤有关。Objective： To observe the effects and explore the potential mechanism of Xingnaojing in sobering acute alcohol poisoning rats up. Methods： Alcohol poisoning rat models were divided into 3 groups randomly. The time of recovery, SOD and MDA in serum was measured. Results： The recovery time was significant shorter in group of Xingnaojing combined naloxone than that in naloxone group and control group. The concentration of SOD was higher in Xingnaojing group than that in naloxone group and control group. Conclusion： Xingnaojing combined naloxone is effective in treating acute alcohol toxicosis rats and the mechanism may be related to the improving ability of clearing free radicals.

关 键 词：酒精中毒 醒脑静注射液 纳洛酮 

分 类 号：R749.62[医药卫生—神经病学与精神病学]