喉鳞状上皮肿瘤中组织嗜酸性粒细胞浸润的诊断意义  

Tissue eosinophil infiltration and its diagnostic significance in larygeal squamous neoplasms

作　　者：胡勇[1] 徐军[1] 章太平[1] 王健[1] 

机构地区：[1]中国人民解放军第105医院病理科,安徽合肥230031

出　　处：《安徽医药》2007年第8期728-729,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的 探讨组织嗜酸性粒细胞（EC）浸润在判断喉鳞状细胞肿瘤是否存在浸润中的意义.方法 回顾性分析82例喉浸润性鳞状细胞癌和浸润前鳞状上皮肿瘤.对每一例肿瘤邻近组织的EC每高倍视野的数量（EC/hpf）和每10个高倍视野的数量（EC/10hpf）分别计数.组织EC增多分为1～4 /hpf,≥5/hpf, 1～9/10hpf and和≥10/10hpf.结果 浸润性癌组织EC浸润比非浸润性肿瘤明显多见.EC增多显著与肿瘤浸润相关,特别在EC计数≥5/hpf和≥10/10hpf时,有较高的特异性和阳性预测值.结论 喉鳞状细胞肿瘤组织EC增多是与肿瘤浸润相关的一个形态学特征,如在活检标本中未发现鳞状上皮肿瘤浸润时提示浸润可能存在;在切除标本未发现浸润时,应深切片或多取材寻找浸润.Aim To investigate whether tissue eosinophilia provides an adjunctive histological criterion for determining the presence of invasion in larygeal squamous neoplasms.Methods 82 cases invasive squamous cell carcinoma and preinvasive squamous neoplasms were retrospectively evaluated.In each case,the number of eosinophils per high power field（EC/hpf）,and EC/10hpf in the tissue adjacent to the neoplastic epithelium,were counted.The elevated eosinophils were defined and categorized as： 1～4 EC/hpf,≥5 EC/hpf,1～9 EC/10hpf and ≥10 EC/10hpf.Results In the invasive carcinoma,elevated eosinophils counts were more frequently seen than in non-invasive neoplasm.The increased eosinophils counts were all statiscally significantly associated with stromal invasion with a high degree of specificity and positive predictive value.Conclusion The eleveted eosinophil count in squamous neoplasia of the larynx is a morphologic feature associated with tumor invasion.

关 键 词：嗜酸性粒细胞 鳞状细胞癌 喉 浸润 

分 类 号：R739.65[医药卫生—肿瘤]