p-AKT和PTEN在Ⅰ型神经纤维瘤病中的表达及意义  

Effect of p-AKT and PTEN on Neurofibromatosis Ⅰ Pathogenesis

作　　者：郭祯[1] 刘林嶓[1] 陈旻静[1] 

机构地区：[1]郑州大学第一附属医院整形外科,河南郑州450052

出　　处：《肿瘤基础与临床》2007年第1期27-28,共2页journal of basic and clinical oncology

摘　　要：目的检测p-AKT和PTEN在Ⅰ型神经纤维瘤病中的表达,进一步探讨其与NF1发生发展的关系。方法应用免疫组化S-P法检测p-AKT、PTEN在26例NF1中的表达情况,与11例正常皮肤对照,并分析表达的相关性。结果p-AKT在正常皮肤中表达阳性率较低(9.09%),在NF1中阳性率升高(53.85%)。PTEN在正常皮肤组织中表达阳性率较高(100.00%),在NF1中表达降低(42.31%)。二者在正常皮肤与NF1中的表达差异均有统计学意义(P<0.05)。经相关性分析,NF1中p-AKT与PTEN的表达呈负相关(r=-0.456,P<0.05)。结论p-AKT、PTEN与NF1的发生发展关系密切。伴随PTEN抑制效应的减弱,p-AKT活性上调,二者共同影响NF1的形成。Objective To investigate the expressions of p-AKT and PTEN in NF1 and make further understanding of the relationship among them in the pathogenesis of NF1. Methods The expression of p-AKT and PTEN in 26 cases with NF1 tissues were detected by the immunohistochemistry, compared with the l l cases with normal skin tissues by the same method, and we analyzd the correlation among them. Resuits The lower positive rate of p-AKT expression was found in normal skin tissues （9. 09% ）. The positive rate increased slightly in NF1 tissues （53.85 % ）. The higher positive rate of PTEN was found in normal skin tissues （ 100.00% ） , and in NF1 tissues the positive rate decreased slightly （42.31%）. There were significant differences in positive rate of them＂ between normal skin tissues and NF1 tissues （ P 〈 0.05）. In NF1 tissues it was revealed by correlation analysis that the expression of PTEN was negatively related to that of p-AKT（ r = - 0.456, P 〈 O. 05）. Conclusions p-AKT and PTEN were closely related with the development of NF1. With the failure of PTEN expression, the expression of p-AKT was more intensive. They influenced the development of NF1.

关 键 词：AKT PTEN Ⅰ型神经纤维瘤病 

分 类 号：R739.43[医药卫生—肿瘤]