CEA,CA72-4在结直肠癌中的临床应用探讨  

The Clinical Application of CEA,CA72-4 in Colorectal Cancer

作　　者：刘利胜[1] 陆作伟[1] 王爱兰[1] 刘玉红[1] 

机构地区：[1]山东省肿瘤医院检验科,山东济南250117

出　　处：《肿瘤基础与临床》2007年第1期43-44,共2页journal of basic and clinical oncology

摘　　要：目的探讨血清肿瘤标志物癌胚抗原(CEA),糖类抗原CA72-4在结直肠癌诊断、术后效果监测、预后判断的应用价值。方法应用电化学发光分析法测定血清中CEA,CA72-4,共测定35例健康成人及91例病理确诊结直肠癌患者,并检测32例术后患者的血清水平。结果对照组CEA为2.1±1.4 ng/mL,CA72-4为4.8±2.1u/mL。结直肠癌患者Dukes B、C、D期CEA,CA72-4均较对照组有明显增高,差异有统计学意义(P<0.05),并且血清水平随临床分期的严重程度而增高。32例术前患者血清CEA为27.9±22.1ng/mL,CA72-4为9.4±6.3u/mL,术后CEA,CA72-4血清水平分别为2.5±1.7 ng/mL,4.5±3.4u/mL,检测结果较术前明显下降,差异有统计学意义(P<0.05)。两者的联合检测可提高诊断的敏感性及有效性,但是特异性有所降低。结论CEA,CA72-4对结直肠癌诊断、术后效果监测、预后判断有意义,但是血清肿瘤标记物诊断敏感性不理想,有必要进行新的肿瘤标记物研究。Objective To discuss the clinical value of CEA,CA72-4 in colorectal cancer . Methods By electrochemiluminescence method, the serum levels of CEA, CA72-4 were measured in 35 healthy adults, 91 patients and 32 postoperative patients. Results The levels of CEA, CA72-4 were 2.1±1.4ng/mL, 4.8 ±2. lu/mL. CEA , CA72-4 were significantly higher in colorectal cancer patients（Dukes B,C, D） than those in control group（ P 〈 0.05 ） , and the levels increased with Dukes stages. In 32 preoperative patients the levels of CEA, CA72- 4 were respectively 27.9±22.1 ng/mL, 9.4±6.3u/mL, when 32 patients were operated, the levels of CEA, CA72-4 were respectively 2.5 ±1.7 ng/mL, 4.5±3.4u/mL, the result was significantly lower than the preoperative result（P 〈 0.05）. The combined application of CEA, CA72-4 could improve the sensitivity and validity, but the specificity was decreased. Conclusions The application of CEA,CA72-4 is important in treatment of colorectal cancer, but sensitivity of serum tumor marker is limited, it is necessary to search new tumor markers.

关 键 词：肿瘤标记物 结直肠癌 癌胚抗原 糖类抗原CA72-4 

分 类 号：R735.34[医药卫生—肿瘤]