肿瘤坏死因子β NcoI位点多态性与胃癌易感性  

Relationship between TNF-β genetic polymorphisms and susceptibility of gastric cancer

作　　者：符刚[1] 沈孝兵[1] 浦跃朴[1] 

机构地区：[1]东南大学公共卫生学院劳动卫生与环境卫生学系,南京210009

出　　处：《中国公共卫生》2007年第8期924-926,共3页Chinese Journal of Public Health

基　　金：东南大学科技基金项目(XJ019004)

摘　　要：目的探讨江苏省南京市汉族人群肿瘤坏死因子β(TNF-β)等位基因多态性与癌易感性的关系,并分析与环境危险因素的交互作用。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对294例胃癌患者及对照进行(TNF-β)基因的单核苷酸多态性(SNP)检测,分析TNF-β基因多态性与胃癌易感性的关系。结合环境危险因素分析,了解TNF-β基因多态性与环境危险因素在胃癌发生中的交互作用。结果TNF-βG/A杂合子是胃癌的危险因素,其在病例组与对照组中的频率分别为50.0%与44.2%,OR=1.6615,95%CI=1.0777～2.5617,P=0.0210),TNF-βA/A出现的频率在胃癌组与对照组比较差异无统计学意义(P>0.05),未发现与环境因素存在交互作用。结论TNF-βG/A杂合子与胃癌的易感性有关。Objective To explore the relationship between TNF-β genetic polymorphisms and susceptibility and the interaction between TNF-β and environmental risk factor. Methods 1 ： 1 case-control study was carried out in Nanjing of gastric carcionma area, the genetic polymorphisms of TNF-β was determined by PCR-RFLP technology, and the epidemiological data about environmental exposure was collected. Results There was significant relationship between TNF-β G/A genotype and susceptibility of gastric cancer（ P = 0. 0210, OR = 1. 6615,95 % CI = 1. 0777- 2. 5617 ）, but no significant relationship between TNF-β A/A genotype and susceptibility gastric cancer（ P 〉 0.05 ）. There was no interaction between genotype of TNF-β and environmental risk factors. Conclusion TNF-β genotype increases risk for gastric cancer.

关 键 词：肿瘤坏死因子Β 基因多态性 胃癌 易感性 

分 类 号：R735.2[医药卫生—肿瘤] R730.2[医药卫生—临床医学]