COX-2、VEGF-C在乳腺癌中的表达及与淋巴转移的关系  

The role of Cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of breast cancer

作　　者：高砚春[1] 吴诚义[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌外科,重庆400016

出　　处：《重庆医科大学学报》2007年第9期915-918,共4页Journal of Chongqing Medical University

基　　金：重庆市卫生局科研项目(03-02-074)

摘　　要：目的:探讨环氧化酶-2(COX-2)、血管内皮生长因子C(VEGF-C)在乳腺癌中的表达及其与乳腺癌淋巴结转移的关系。方法:采用免疫组化法(SP法),检测45例乳腺癌组织中COX-2、VEGF-C的蛋白表达情况,分析其与患者年龄、肿瘤大小、雌、孕激素受体状况、临床分期、腋窝淋巴结转移的关系。结果:在45例乳腺癌组织中,COX-2、VEGF-C蛋白表达的阳性率分别为84.4%(38/45)和71.1%(32/45)。二者在Ⅲ+Ⅳ期乳腺癌中的阳性表达率明显高于Ⅰ+Ⅱ期乳腺癌,分别为93.3%:66.7%和83.3%:46.7%(P<0.05),在腋窝淋巴结阳性组表达率高于腋窝淋巴结阴性组,分别为92.9%:70.6%和82.2%:52.9%(P<0.05),但与患者年龄、肿瘤大小、雌激素、孕激素受体状况等无明显相关性(P>0.05)。COX-2阳性的乳腺癌组织VEGF-C表达率高于COX-2阴性组,分别为76.2%:43.6%(P<0.05)。COX-2与VEGF-C在乳腺癌中的表达成正相关(r=0.579,P<0.05)。结论:乳腺癌组织中,COX-2、VEGF-C表达均与肿瘤临床分期、腋窝淋巴结转移呈明显相关关系。COX-2可促使肿瘤细胞分泌VEGF-C,促进淋巴结转移增加。Objective：To investigate the expression of Cyclooxygenase-2 （COX-2）and vascular endothelial growth factor-C （VEGF-C） proteins,and their relationship with lymphatic metastasis of breast cancer. Method, s：Immunohistochemical staining was used to detect the expression of COX-2 and VEGF-C proteins in 45 cases of breast cancer. The relationship was analyzed between the expression of VEGF-C,COX-2 and age,tumor size,the protein expression of estrogen receptor （ER） and progesterone receptor （PR）,clinic phase,axillary lymph node metastasis. Resu/ts：The expression rates of COX-2 and VEGF-C in Ⅲ and Ⅳ stages of breast cancer were higher than those of Ⅰ and Ⅱ stages （P〈0.05）. There was higher expression in the positive group of axillary lymphnode metastasis than that in the negtive group （P〈0.05）. However,there were no correlations with ages,tumor size,ER and PR,etc. The expression rate of VEGF-C in the COX-2-positive group was higher than that in the negtive group,which were 76.2% vs 43.6%,respectively （P〈0.05）.The expression of COX-2 and VEGF-C in breast cancer showed a positive correlation （r=0.579,P〈0.05） Conclusions：In breast cancer,The expression of COX-2 is significantly associated with clinic stage and axillary lymph node metastasis,and COX-2 could promote tumor cells to secrate VEGF-C and then accelerate lymphatic metastasis.

关 键 词：乳腺肿瘤 环氧化酶-2 VEGF-C 淋巴转移 

分 类 号：R737.9[医药卫生—肿瘤]