氟西汀与三环类抗抑郁药物治疗抑郁症引发失眠、焦虑、激越与躁狂的Meta分析  

Meta-analysis of Differences on Incidence of Insomnia,Anxiety,Irritability and Mania Induced by Fluoxetine and Tricyclic Antidepressants(TCA)

作　　者：童振华[1] 王佩蓉[1] 金卫东[1] 马永春[1] 陈炯[1] 陈正昕[1] 王鹤秋[1] 

机构地区：[1]浙江省立同德医院浙江省精神卫生中心,浙江省杭州市310012

出　　处：《中国全科医学》2007年第16期1327-1329,共3页Chinese General Practice

基　　金：浙江省卫生厅医药科研基金资助项目(2006A017)

摘　　要：目的分析氟西汀与三环类抗抑郁药物(TCA,包括马普提林)治疗抑郁症引发失眠、焦虑、激越与躁狂的差异。方法应用循证医学的Meta分析,采用Peto固定效应模型(fixed effects model,FEM)法对符合标准的35项对照研究文献进行评价。结果氟西汀与TCA治疗抑郁症出现失眠、激越间差别有显著性意义(P<0·05);焦虑、躁狂发作间差别无显著性意义(P>0·05)。结论在治疗抑郁症中,氟西汀比TCA更可引发失眠、激越,应特别加以关注。Objective To compare the differences of insomnia, anxiety, irritability, and manic episode induced by fluoxetine and tricyclic antidepressants （TCA）, Methods The 35 standard control study records were analyzed by fixed effects model, meta- analysis of evidence - based medicine （EBM）, Results Significant differences on incidence of insomnia and irritability were found （ P 〈 0, 05）, but no difference on incidence of anxiety and manic episode induced by fluoxetine and TCA was found （ P 〉0, 05 ）. ConclusionFluoxetine is more liable to induce insomnia, irritability than TCA during the treatment for depression, and this should be give enough attention,

关 键 词：氟西汀 抑郁药物 三环 循证医学 

分 类 号：R749.42[医药卫生—神经病学与精神病学]