DEC1在肺癌中表达及其临床意义  

Expression of Differentiated Embryo-Chondrocyte Expressed Gene 1(DEC1)in Lung Cancer and Its Clinical Significance

作　　者：李清泉[1] 张莉[2] 

机构地区：[1]武汉大学人民医院,湖北武汉430060 [2]武汉大学中南医院,湖北武汉430071

出　　处：《中国肿瘤》2007年第8期628-630,共3页China Cancer

摘　　要：[目的]探讨DEC1在肺癌中的表达以及临床意义。[方法]运用免疫组化技术检测56例肺癌中DEC1、HIF-1α、bcl-2和caspase-3的表达。[结果]DEC1蛋白在肺癌阳性表达率分别为55.36%,高于肺良性病变组织中的阳性表达率(23.81%)(P<0.05)。DEC1在肺癌中的表达与HIF-1α表达水平相关,但与bcl-2和caspase-3的表达水平无关,并与患者性别年龄、肿瘤大小、TNM分期、组织学分型及有无淋巴结转移均无关。[结论]DEC1在肺癌的发生发展中可能起着重要的作用,其表达与HIF-1α有关,且可能通过不依赖bcl-2和caspase-3的途径影响肺癌细胞的凋亡。[Purpose] To investigate the expression of differentiated embryo-chondrocyte expressed gene 1 （DEC1） in lung cancer and its clinical significance. [Methods] The expressions of DEC1, HIF-1α , bcl-2 and caspase-3 in 56 cases with lung cancer were detected by immnohistochemsitry. [Results] The positive expression rate of DEC1 in lung cancer tissues was 55.36%（31/56）, which was significantly higher than that in benign lesion tissues （23.81%）（P〈0.05）. The expression of DEC1 in lung cancer was related to HIF-1α protein level, but was not related to bcl-2 and caspase-3 protein levels. DEC 1 expression was not correlated with patients＇ age, sex, TNM staging, lymph node involvement and histological type. [Conclusion] DEC1 may paly a role in the carcinogenesis and development of lung cancer. The expression of DECI may be related to HIF-1α in lung cancer, and affect cell apoptosis not rely on bcl-2 and caspase-3 route.

关 键 词：肺肿瘤 免疫组化 DEC1 HIF-1Α 

分 类 号：R734.2[医药卫生—肿瘤]