补肾方剂对骨质疏松大鼠纯钛种植体骨结合影响的骨计量学研究  

Effect of tonifying kidney recipes on osseointegration around titanium implants in osteoporotic rats

作　　者：郝福良[1] 董福生[1] 任贵云[1] 张旭东[1] 宋静[1] 栗兴超[1] 

机构地区：[1]河北医科大学口腔医学院口腔颌面外科,050017

出　　处：《实用口腔医学杂志》2007年第4期507-510,共4页Journal of Practical Stomatology

基　　金：河北省自然科学基金资助项目(编号:300359)

摘　　要：目的:观察补肾方剂对骨质疏松大鼠纯钛种植体骨结合的影响,探讨补肾方剂促进纯钛种植体骨结合的机制。方法:选用纯种8月龄雌性SD大鼠54只,随机分为3组。A组:假手术组,B组:卵巢切除组,C组:卵巢切除加中药治疗组。在3组大鼠胫骨近中干骺端分别植入纯钛光滑柱状种植体。C组大鼠用补肾方剂灌胃。种植术后1、2、3个月,取出带种植体的胫骨,制作HE染色的组织切片,骨计量学观察。结果:C组的骨小梁宽度、结合骨板宽度、松质骨区骨量、成骨细胞数均明显大于B组(P<0.01)。结论:补肾方剂可以使骨质疏松大鼠种植体周围的成骨细胞数增加,松质骨区骨量明显增加,促进骨改建,提高骨结合的质量。Objectlve：To investigate the mechanism of the effect of tonifying kidney recipes（TKR） on osseointegration of the Titanium Implants by established animal model of osteoporosis rats. Methods ： Fifty-four female SD rats were randomly divided into three groups ： A ： Sham group, B ： ovariectomy （OVX） group C ： OVX ＋ TKR group. After operation, tonifying kidney recipes was given orally in C group. The results were observed by bone histomorphometry. Results：Trabeculae area （Tb · Ar,% ）, trabeculae width （Tb · Wi）, combined bone lamella width （CBLW）, osteoblast number （OB · N） in C group were significantly increased compared with B group （P 〈0. O1 ）. Conclusion：Tonifying kidney recipes can increase the number and activity of osteoblasts and promote the synthesis of bone matrix to promote osseointegration of dental implants. Tonifying kidney recipes can improve osseointegration of titanium implant in osteoporosis：

关 键 词：纯钛种植体 骨结合 骨质疏松 补肾方剂 骨计量学 

分 类 号：R285.5[医药卫生—中药学]