3～4岁儿童唾液蛋白含量的研究  

Salivary proteins in children aged from 3 to 4 years

作　　者：林琴[1] 白洁[2] 包振英[1] 周琼[2] 秦满[2] 

机构地区：[1]北京大学口腔医学院检验科,100081 [2]北京大学口腔医学院儿童口腔科

出　　处：《实用口腔医学杂志》2007年第4期568-570,共3页Journal of Practical Stomatology

基　　金：首都医学发展科技基金(编号:2002-3035)

摘　　要：目的：探讨3—4岁无龋儿童非刺激性和刺激性唾液中IgA、乳酸脱氢酶、碱性磷酸酶、溶菌酶和总蛋白含量的差异，为研究婴幼儿的唾液成分提供基础数据。方法：采集北京市区94名3—4岁无龋儿童刺激性和非刺激性唾液各2ml，测定唾液中的IgA、乳酸脱氢酶、碱性磷酸酶、溶菌酶和总蛋白的含量。结果-女性非刺激性唾液总蛋白含量显著低于男性（P〈0．05）；其余各成分在男性和女性唾液中的含量均无显著差异（P〉0．05）。刺激性唾液中IgA含量显著低于非刺激性唾液（P〈0．01），而乳酸脱氢酶和总蛋白含量显著高于非刺激性唾液（P〈0．01）；刺激性和非刺激性唾液中，碱性磷酸酶和溶菌酶的含量无显著差异（P〉0．05）。结论：3～4岁儿童刺激性和非刺激性唾液中蛋白成分不同，男女间唾液蛋白成分也不完全相同。Objective： To explore levels of salivary IgA, lysozyme, lactate dehydrogenase, alkaline phosphatase and total proteins in unstimulated （UWS） and stimulated （SWS） whole saliva of caries-free children. Methods： 94 caries-free children, aged from 42 to 54 months, were recruited from urban kindergartens in Beijing. 2 ml UWS and 2 ml SWS were collected from each child to measure salivary IgA, lysozyme, lactate dehydrogenase, alkaline phosphatase and total proteins. Results：l ） There were no differences in salivary proteins between boys and girls in both UWS and SWS, except total proteins. In UWS, the concentration of total proteins in girls was lower than that in boys （ P 〈 0.05 ）, while in SWS, the concentration was similar between girls and boys （P 〉 0.05 ）. 2） The concentration of IgA in SWS was significantly lower than that in UWS （P 〈 0.01 ）. The concentrations of lactate dehydrogenase and total protein in SWS were higher （P 〈 0.01 ）. There were no significant differences in alkaline phosphatase and lysozyme between UWS and SWS （ P 〉 0.05 ）. Conclusion ： In 3- to 4- year old children, the protein composition in stimulated whole saliva is different from that in unstimulated whole saliva, and it is also different between genders. Therefore, it is more reliable to measure salivary proteins in both UWS and SWS when studying saliva of children.

关 键 词：唾液蛋白 刺激性唾液 非刺激性唾液 无龋儿童 

分 类 号：R788[医药卫生—口腔医学]