p120^ctn在乳腺癌中的表达及意义  

The expression and significance of p120^ctn in invasive breast cancer

作　　者：杨剑锋[1] 陈森林[2] 刘志红[2] 高妮娜[2] 李程[1] 

机构地区：[1]湖南师范大学医学院病理教研室,湖南长沙410006 [2]湖南省肿瘤医院病理科

出　　处：《中国医师杂志》2007年第7期893-895,共3页Journal of Chinese Physician

基　　金：湖南师范大学青年基金资助项目（29040623）;湖南省教育厅科研资助项目（04C354）

摘　　要：目的 探讨乳腺癌组织中p120^ctn的表达。方法采用免疫组织化学SP法检测50例乳腾癌组织中E-cadherin、p120^ctn的表达。结果 乳腺癌组织中有29例（58％）E—cadherin表达异常，37例（74％）p120^ctn的表达异常，其中35例（70％）胞浆内异位表达。E-cadherin膜表达下降与p120^ctn的胞浆异位表达呈正相关（rs=0．53，P〈0．01）。p120^ctn 在浸润性小叶癌中的异常表达率（94．4％）明显高于浸润性导管癌（62．5％），P〈0．05。p120^ctn异常表达与分化程度相关（P〈0．05）。但p120^ctn异常表达与TNM分期、淋巴结转移与否无显著相关性（P〉0．05）。结论 p120^ctn在乳腺癌组织中呈异常表达，并与E-cadherin表达相关，在乳腺癌发生、发展中可能起着重要作用；p120^ctn与浸润性小叶癌的发生和发展更为密切。Objective This study was performed to determine the expression of p120^ctn in breast cancer to investigate its correlation with the clinical and pathologic parameters. Method We studied the alterations of E - cadherin, p120^ctn in 50 cases of breast cancer by high sensitive SP immunohistochemical method, Results The abnormal expression rates of E - cadherin, p120^ctn were 58% （29/50） ,74% （37/50） respectively. There were 35（70% ） cases showed abnormal cytoplasmic staining of p120^ctn. Reduction of E - cadherin in membrane and abnormal cytoplasmic staining of p120^ctn showed a significantly positive correlation （ r, = 0. 53, P 〈 0. 01 ）. The abnormal expression rate of p120^ctn in ILC was significantly higher than that in IDC （ P 〈0, 05）, There was a significant correlation between abnormal expression of p120^ctn and tumor differentiation （ P 〈0, 05）, but no correlation with clinical stage and lymph node metastasis （ P 〉0, 05）. Conclusion The expression of p120^ctn is abnormal in breast carcinoma and there is a significant correlation in expression of E -cadherin and p120^ctn, p120^ctn may play an important role in cell transformation and tumor progression in breast cancer, especially in lobular breast cancer.

关 键 词：乳腺肿瘤 细胞粘附分子 钙粘着糖蛋白类 

分 类 号：R737[医药卫生—肿瘤]