后程低分割适形放射治疗Ⅲ期肺鳞癌的Ⅰ期临床研究  

The PhaseⅠ Trial of the Late-Course Hypofractionation 3-Dimensional Conformal Radiotherapy (3-DCRT) for Stage Ⅲ Lung Squamous Carcinoma

作　　者：贺秋冬[1] 杨立[1] 

机构地区：[1]南华大学第一附属医院放疗科,湖南衡阳421001

出　　处：《肿瘤基础与临床》2007年第4期326-327,共2页journal of basic and clinical oncology

摘　　要：目的 研究Ⅲ期肺鳞癌后程低分割适形放疗的早期毒副反应和近期疗效。方法 89例符合条件的患者进入研究组,其中4例未完成治疗计划而被剔除。前4周采用6 MV X线胸前背后对穿外照射,DT40 Gy/20次,后程放疗采用3-DCRT补量,DT30 Gy/10次,2周。结果 急性放射性肺炎（Ⅰ-Ⅲ级）24.7%,Ⅳ级0,急性放射性食管炎（Ⅰ-Ⅱ级）28.2%,骨髓抑制Ⅰ-Ⅱ级8.2%,Ⅲ-Ⅳ级0,肿块治疗总有效率为81.2%。结论 Ⅲ期肺鳞癌常规放疗＋后程低分割适形放疗近期疗效满意,早期毒副反应可以耐受。Objective To study early therapeutic efficacy and side effects of late-course hypofractionation 3-dimensional conformal radiothera- py（3-DCRT） for stage nl lung squamous carcinoma. Methods 89 patients with stage nl lung squamous carcinoma were enrolled ,but 4 of all the cases were excluded because of metastasis or other diseases. During radiation therapy,anterior-posterior （A-P） irradiation field was opposed to posterior-anterior （P-A） irradiation field by 6 MV X linear accelerator in first four weeks, the tumor dose（DT） was 40 Gy/20 F, 4 weeks, the late-course hypofractionation 3-dimensional conformal radiotherapy（3-DCRT） was adopted late. The tumor dose （DT） was 30 Gy/10 F,2 weeks. Results The incidence of acute radiation pneumonia was 24.7% （ grade Ⅰ～Ⅲ）, 0% （ grade Ⅳ ） respectively, the incidence of acute radiation esophagitis was 28.2% （ grade Ⅰ - Ⅱ ）, the incidence of bone marrow suppression was 8.2% （ grade Ⅰ-Ⅱ ）, 0% （ grade Ⅲ - Ⅳ ） respectively. The total reaction incidence of tumor mass was 81.2%. Conclusions Phase I trial of conventional radiotherapy followed by the late-course hypofractionation 3-dimensional conformal radiotherapy （3-DCRT） for stage nl lung squamous carcinoma is acceptable.

关 键 词：肺鳞癌 常规放疗 低分割放疗 后程三维适形放疗 

分 类 号：R734.2[医药卫生—肿瘤] R730.55[医药卫生—临床医学]