新辅助化疗中凋亡效应因子caspase-7、caspase-3及凋亡抑制因子survivin关系初探  

The preliminary study of the relationship between caspase-7,caspase-3 and survivin under neoadjuvant chemotherapy.

作　　者：胡会华[1] 周士福[2] 李青国[3] 

机构地区：[1]四川省自贡市第四人民医院,643000 [2]苏州大学附属第四医院普通肿瘤外科 [3]淮安妇幼保健院

出　　处：《中国综合临床》2007年第10期896-898,共3页Clinical Medicine of China

摘　　要：目的探讨凋亡效应因子caspase-7、caspase-3及凋亡抑制因子survivin之间的相互关系。方法免疫组织化学法检测17例乳腺癌新辅助化疗标本中caspase-7、caspase-3、survivin的表达,统计分析采用Fisher确切概率法、Spearman检验。结果化疗前后三者阳性率比较,仅caspase-7差异有统计学意义(P =0.038);caspase-3、survivin差异无统计学意义(均P>0.05)。化疗前三者表达强度未见相关性(均P>0.05)。化疗后表达强度caspase-3与caspase-7、survivin相关,P值分别为0.009、0.000;survivin与caspase-7无相关性。化疗前后三者表达强度变化比较,仅caspase-7与caspase-3相关(P=0.035);余未见相关性。结论caspase-7、caspase-3表达相关,但caspase-7可能不依赖caspase-3而表达,survivin与caspase-7、caspase-3之间无相关性,也不能抑制后两者的表达,三者关系尚需进一步研究。Objective To study the relationship between caspase-7, and caspase-3 with survivin. Methods The expression of caspase-7, caspase-3 and survivin were examined in 17 patients with breast cancer receiving neoadjuvant chemotherapy by immunohistochemistry. Fisher and Spoarman test were adopted. Results The significant difference was seen in the positive rate of caspase-7 before and after chemotherapy （ P = 0.03 ） but there was no difference in caspase-3 and surviving （ P 〉 0.05 ） . Before chemotherapy, there was no correlation among their expression （P 〉 0.05 for each ）. After chemotherapy,the expression of caspase-3 was correlated with caspase-7 and survivin （ P = 0.009,0.000 ）, and the significant correlation was seen among their changes of caspase-7 and caspase-3 （ P = 0. 035 ）. Conclusion The expression of caspase-7 is correlated with caspase-3, but it may be independent of caspase-3. Survivin is not correlated with caspase-7 and caspase-3 ,which can not inhibit their expression.

关 键 词：天冬氨酸特异性半胱氨酸蛋白酶17 天冬氨酸特异性半胱氨酸蛋白酶-3 生存素 

分 类 号：R737.9[医药卫生—肿瘤]