^(111)In-DTPA-octreotide的标记条件研究及初步动物实验  

LABELING STUDY ON 111 In OCTREOTIDE AND PRIMARY ANIMAL TESTS

作　　者：王凡[1] 樊红强[1] 肖伦[1] 王翌善[1] 金小海[1] 陈大明[1] 白宏升[1] 程震[1] 杜进[1] 

机构地区：[1]中国原子能科学研究院同位素研究所

出　　处：《同位素》1997年第1期16-20,共5页Journal of Isotopes

摘　　要：研究了一步法不经纯化１１１Ｉｎ标记生长激素抑制素（ＳＭＳ）类似物ＤＴＰＡ－ｏｃｔｒｅｏｔｉｄｅ的标记条件，其中包括反应时间、ＤＴＰＡ－ｏｃｔｒｅｏｔｉｄｅ用量、反应体积等。标记率达９９％，比活度为２７７．５ＰＢｑ／ｍｏｌ，产物的放化纯度＞９９％。对标记物的稳定性及其在小鼠体内的分布也进行了观察。Octreotide, a somatostatin analogue, is a useful ligand for in vitro detection of somatostatin receptor. 111 In DTPA octreotide can be used for the visualization of somatostatin receptor positive tumors by gamma camera scintigraphy. In the paper, the labeling condition including the effects of reaction time, the DTPA octreotide quantity and the reaction volume on labeling yield are studied. The labeling yield is analysed by HPLC, and it reaches up to 99% without further purification. Spectific activity of radiolabeled compound is 277.5 PBq/mol, the radiochemical purity is more than 99%. The in vitro stability of 111 In DTPA octreotide and the biodistribution in rats are measured. It is shown that the radiochemical purity decreases with stock time and the %ID·g 1 in adrenals is higher than other organs. 111 In DTPA octreotide clearance in tissues is slower than that of 111 In DTPA.

关 键 词：DTPA 铟111 标记条件 生物分布 肿瘤显像 

分 类 号：R730.44[医药卫生—肿瘤]