后程超分割治疗与鼻咽癌大容积原发肿瘤疗效关系的研究  

The effects of treatment in large primary tumor volume with late hyperfractionated radiation therapy and conventional fractionated radiation therapy of nasopharyngeal carcinoma

作　　者：师颖瑞[1] 吴湘玮[1] 陈艳平[1] 张九堂[1] 范长根[1] 韩亚骞[1] 

机构地区：[1]湖南省肿瘤医院放疗一科

出　　处：《现代肿瘤医学》2007年第8期1078-1080,共3页Journal of Modern Oncology

摘　　要：目的:探讨常规分割放疗(CFRT)与后程超分割放疗(LHRT)对鼻咽癌大容积(≥60cm3)原发肿瘤的疗效关系。方法:无远处转移的182例初治鼻咽癌(T2～4N0～3Mo)。治疗前根据CT资料勾画鼻咽癌原发肿瘤,容积(≥60cm3),采用CFRT或LHRT照射,N3的病例均加用辅助化疗,分析比较两组疗效。结果:鼻咽癌大容积≥60cm3原发肿瘤无论T分期,采用LHRT较CFRT治疗,患者原发灶5年控制率对比有统计学意义。N0～2的患者无远处转移生存率对比,亦有统计学意义。结论:鼻咽癌大容积原发肿瘤无论T分期,(N0～2)后程采用超分割照射可提高鼻咽癌控制率及无瘤生存率,但N3的患者虽鼻咽癌控率可提高,但无远处转移生存率未见统计学意义的差异。Objective：To investigate the effect of larger primary tumor of nasopharyngeal cancer （NPC） treated with conventional fractionated radiation therapy （CFRT） or LHRT. Methods： One hundred and seventy -two patients without distance relapse diagnosed as low differentiated squamous NPC （T2 -4 N0-3 M0 ） were inrolled in the stucly and all accepted chemical treatment. The primary tumor lesion was first described by CT images and the volume was larger than 60cm^3. Results： 5 -years local control rates of patients treated by LHRT and CFRT had statistical significance. The statistical significance also oppeared in distant relapse - free survival rates in the patients of N0-2. Conclusion： For the lager volume （ ≥60cm^3） primary tumor of NPC , LHRT can rise the control and disease -free rate.

关 键 词：鼻咽癌 大容积原发肿瘤 超分割放疗 

分 类 号：R739.63[医药卫生—肿瘤]