海洛因成瘾相关基因多态性研究进展  

Advance of Polymorphisms in the Genes Related to Heroin Addiction

作　　者：张恒[1] 褚嘉祐[1] 

机构地区：[1]中国医学科学院中国协和医科大学医学生物学研究所医学遗传室,昆明650118

出　　处：《国际遗传学杂志》2007年第4期302-306,共5页International Journal of Genetics

摘　　要：海洛因依赖是种不顾后果的强制性寻觅和使用海洛因的行为，它不仅与心理因素和社会因素相关，还是种机制复杂的中枢神经功能失调。遗传流行病学研究表明遗传因素在海洛因依赖上起很大作用，多巴胺能神经系统和单胺能神经系统相关基因多态性与海洛因成瘾易感性有一定关系。Heroin addiction can be considered as a loss of control heroin taking, or compulsive heroin-seeking and taking despite horrendous consequences. Although it involves many psychological and social factors, it is widely accepted that heroin addiction is a central nervous system disorder of complicated mechanisms related to dopaminergic neurons and monoaminergic neurons. Genetic epidemiologic studies support a high degree of heritable vulnerability for heroin dependence and polymorphisms in the dopaminergic- related genes and monoaminergic-related genes appear to contribute to individual risk for addiction.

关 键 词：海洛因 多态性 基因 

分 类 号：R74[医药卫生—神经病学与精神病学]