家兔急性不完全性脑缺血及重灌流的实验病理研究  

Experimental studies on acute incomplete cerebral ischemic and reperfusion damages in rabbits

作　　者：高彩荣[1] 王英元[1] 路健[1] 王亚方[1] 

机构地区：[1]山西医科大学法医学系

出　　处：《山西医科大学学报》1997年第1期4-6,共3页Journal of Shanxi Medical University

基　　金：山西省青年科学基金

摘　　要：采用低压低灌流方法造成家兔急性不完全性脑缺血，并进行重灌流。检测了脑电图（ＥＥＧ）及大脑组织中乳酸脱氢酶（ＬＤＨ）活性，观察了大脑皮层组织形态学变化。结果发现，脑缺血时大脑ＥＥＧ明显抑制，ＬＤＨ活性升高，脑组织超微结构表现为膜结构损伤。重灌流后ＥＥＧ严重抑制，ＬＤＨ活性升高，膜结构损伤进一步加重。Acute incomplete cerebral ischemia was induced by bloodletting hypotension in rabbits and was followed by reperfusion.The electroencephalogram and the activities of lactic dehydrogenase(LDH) in cerebral tissue were measured.The histological and ultrastructural alterations were observed.The results were as follows:① There were severe suppression of eletroencephalographic activity,elevation of LDH activity and cellular membrane damage after acute incomplete cerebral ischemia.②The similar and more severe changes were observed during reperfusion peroid.

关 键 词：脑缺血 缺血后再灌流 脑电图 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]