TCF方案与PF方案治疗晚期食管癌的临床研究  

Study of TCF regimen and PF regimen for advanced carcinoma of esophagus

作　　者：倪雪峰[1] 吴昌平[1] 王赫[1] 

机构地区：[1]常州市第一人民医院肿瘤科

出　　处：《临床肿瘤学杂志》2007年第7期509-511,共3页Chinese Clinical Oncology

摘　　要：目的:观察比较紫杉醇联合顺铂、氟尿嘧啶(TCF方案)与顺铂加氟尿嘧啶(PF方案)两个方案治疗晚期食管癌的临床疗效和毒性反应。方法:共69例患者,分别用TCF、PF方案化疗,28天为1个周期。2个周期以后按照WHO标准进行疗效评价。结果:TCF方案可评价疗效者32例,CR2例,PR15例,有效率53.1%。中位疾病进展时间为5.4个月,中位生存时间10.1个月。可评价毒副反应33例。主要不良反应为脱发、中性粒细胞降低,恶心、呕吐也较常见。PF方案可评价疗效者29例,PR14例,有效率48.3%。中位疾病进展时间3.9个月,中位生存期8.7个月。主要不良反应为恶心、呕吐。结论:TCF方案对晚期食管癌疗效好,毒副反应可耐受,可以考虑作为治疗晚期食管癌的主要治疗方案。Objective： Paclitaxel combining with cisplatin and 5-fluorouracil or cisplatin and 5-fluorouracil were used in advanced esophageal cancer, comparing with difference between two groups in chemotherapy response and toxicity. Methods：Sixty-nine patients were allotted. In trial group, patients were given paclitaxel, cisplatin and 5-fluorouracil on d1 -d5. In control group, patients were given cisplatin and 5-fluorouracil. Treatment was recycled every 28 days. Chemotherapy response were evaluated after 2 cycles according WHO standard. Results： In trial group ,32 patients were evaluable for response. Major objective responses were observed in 17 patients（53.1% ）. The median time to tumor progression was 5.4 months. The median survival time was 10. 1 months. The most com- mon toxicity was alopecia, neutropenia and nausea/vomiting. While in control group, 29 patients were evaluable for response. Major objective responses were observed in 14 patients（48. 3% ）. The median time to tumor progression was 3.9 months. The median survival time was 8. 7 months. The most common toxicity was nausea/vomiting. Conclusion： In advanced esophageal cancer, combination with paclitaxel, cisplatin and 5-fluouracil could be considered as a main regimen. It is effective and toxicity is tolerable

关 键 词：食管癌 紫杉醇 顺铂 氟尿嘧啶 

分 类 号：R730.53[医药卫生—肿瘤] R735.1[医药卫生—临床医学]